Fluorescence Guided Surgery with 5-Aminolevulinic Acid for Resection of Spinal Cord Ependymomas

Rafael García Moreno; Luis Miguel Bernal García; Hyaissa Ippolito Bastidas; Carlos Andrés Mondragón Tirado; Aurora Moreno Flores; Juan Pablo Sosa Cabezas; José Manuel Cabezudo Artero

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자료유형: 학술저널

저자정보: Rafael García Moreno (University Hospital Complex of Badajoz) Luis Miguel Bernal García (University Hospital Complex of Badajoz) Hyaissa Ippolito Bastidas (University Hospital Complex of Badajoz) Carlos Andrés Mondragón Tirado (University Hospital Complex of Badajoz) Aurora Moreno Flores (University Hospital Complex of Badajoz) Juan Pablo Sosa Cabezas (University Hospital Complex of Badajoz) José Manuel Cabezudo Artero (University Hospital Complex of Badajoz)

저널정보: 대한척추외과학회 Asian Spine Journal Asian Spine Journal Vol.13 No.1

발행연도: 2019.1

수록면: 119 - 125 (7page)

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Study Design: A retrospective study. Purpose: We report our experience with 5-aminolevulinic acid (5-ALA)–assisted resection of spinal cord ependymomas in adults. Overview of Literature: Ependymoma is the most frequent primary spinal cord tumor in adults. Surgery is the treatment of choice in most cases. However, while complete resection is achieved in approximately 80% of cases, clinical improvement is achieved in 15% only. Five-ALA fluorescence–guided surgery seems to be useful for this tumor type. Methods: We studied 14 patients undergoing 5-ALA fluorescence-guided surgery for spinal cord ependymomas in our service. The modified McCormick classification was used to determine clinical status and the degree of resection was assessed with magnetic resonance imaging. Results: Of the 14 patients, the tumor showed an intense emission of fluorescence in 12 and the fluorescence was weak and nonuniform in two. Complete resection was achieved in 11 cases. According to the McCormick classification, 10 patients improved, two remained the same, and two deteriorated. Conclusions: Our results confirm that 5-ALA fluorescence-guided resection is useful in spinal cord ependymoma resection. Although the rate of complete resections is similar to that in published series without 5-ALA, clinical results are better when using 5-ALA with a lower percentage of clinical deterioration.

#Spinal cord #Ependymoma #Aminolevulinic acid #Fluorescence guided surgery Copyright

참고문헌 (30)

참고문헌 신청

Louis DN / 2007 / WHO classification of tumours of the central nervous system / International Agency for Research on Cancer Press

Miller DC / 2000 / Surgical pathology of intramedullary spinal cord neoplasms / J Neurooncol 47:189~194

Samii M / 1994 / Surgical results of 100 intramedullary tumors in relation to accompanying syringomyelia / Neurosurgery 35:865~873

Stummer W / 2006 / Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial / Lancet Oncol 7:392~401

Arai T / 2006 / Intraoperative photodynamic diagnosis for spinal ependymoma using 5-aminolevulinic acid : technical note / No Shinkei Geka 34:811~817

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