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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한노인병학회 Annals of geriatric medicine and research Annals of geriatric medicine and research Vol.25 No.1
- 발행연도
- 2021.1
- 수록면
- 39 - 44 (6page)
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초록· 키워드
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Background: A comprehensive visual rating scale (CVRS) using brain magnetic resonance imaging (MRI) was previously developed to evaluate structural changes in the brains of older patients. This study investigated the usefulness of the CVRS in predicting dementia with Alzheimer disease (AD) in patients with prodromal AD. Methods: We included 189 patients with prodromal AD with available data from the Alzheimer’s Disease Neuroimaging Initiative study. We evaluated all patients using CVRS and assessed their progression to AD dementia over 3 years of longitudinal follow-up. Survival analysis was performed using the Cox proportional hazards model to analyze the hazard ratios of the CVRS for progression to AD dementia. Results: Among 189 patients with prodromal AD, 61 (32.3%) progressed to dementia. The mean baseline CVRS scores differed significantly between the stable and progressive groups (9.9±5.1 vs. 12.4±4.9; p=0.002). An initial high CVRS score was an independent risk factor for the progression to AD dementia (hazard ratio=1.110; 95% confidence interval, 1.043–1.182). Conclusion: The baseline CVRS score predicted the progression to dementia in patients with prodromal AD, indicating its independent association with longitudinal cognitive decline.
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등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
Dubois B / 2014 / Advancing research diagnostic criteria for Alzheimer's disease : the IWG-2 criteria / Lancet Neurol 13:614~629
van Maurik IS / 2017 / Interpreting biomarker results in individual patients with mild cognitive impairment in the Alzheimer's Biomarkers in Daily Practice(ABIDE)project / JAMA Neurol 74:1481~1491
Chandra A / 2019 / Magnetic resonance imaging in Alzheimer's disease and mild cognitive impairment / J Neurol 266:1293~1302
McKhann GM / 2011 / The diagnosis of dementia due to Alzheimer's disease : recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease / Alzheimers Dement 7:263~269
Albert MS / 2011 / The diagnosis of mild cognitive impairment due to Alzheimer's disease : recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease / Alzheimers Dement 7:270~279
van Maurik IS / 2017 / Interpreting biomarker results in individual patients with mild cognitive impairment in the Alzheimer's Biomarkers in Daily Practice(ABIDE)project / JAMA Neurol 74:1481~1491
Chandra A / 2019 / Magnetic resonance imaging in Alzheimer's disease and mild cognitive impairment / J Neurol 266:1293~1302
McKhann GM / 2011 / The diagnosis of dementia due to Alzheimer's disease : recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease / Alzheimers Dement 7:263~269
Albert MS / 2011 / The diagnosis of mild cognitive impairment due to Alzheimer's disease : recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease / Alzheimers Dement 7:270~279
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