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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 86 - 92 (7page)
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Background: The new kidney allocation system in the United States has introduced longevity matching, which gives priority to allocating the best quality organs to wait-listed candidates with the longest predicted survival for the efficient utilization of organs that are of limited availability. The estimated post-transplant survival (EPTS) score was developed in the United States to risk-stratify all wait-listed patients. However, prognostic indices used in Western countries were derived from data that may be different for Korea and do not necessarily reflect prognostic values for Korean deceased donor kidney transplantation. Prognostic indices for Korean wait-listed candidates therefore need to be developed from Korean data. Methods: We analyzed 6,731 adult solitary kidney transplant patients for candidate risk prediction using the national data from the Korean Network for Organ Sharing (KONOS) and National Health Insurance Data Sharing Service (NHISS). Cox regression analysis was used to model the risk of patient death. Results: The Korean EPTS (K-EPTS) score was developed based on four recipient parameters (age, diabetes mellitus, hepatitis C virus, and duration of dialysis) that showed a significant association with post-transplant survival. K-EPTS scores showed good discrimination (C-statistics: 0.690; 95% confidence interval, 0.666–0.715). Moreover, the ability of the K-EPTS score to discriminate patient survival was better than that of the EPTS according to the criteria of the United Network for Organ Sharing (US-EPTS) score (P<0.001). Conclusions: The K-EPTS score, which was developed based on Korean national data, is expected to contribute to the assessment of recipient prognosis and efficient utilization of deceased donor kidneys.
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참고문헌 (16)
참고문헌 신청
United Network for Organ Sharing (UNOS) / OPTN policy 3.5: allocation of deceased kidneys
Organ Procurement and Transplantation Network (OPTN) / Proposal to substantially revise the national kidney allocation system
Rao PS / 2009 / A comprehensive risk quantification score for deceased donor kidneys the kidney donor risk index / Transplantation 88:231~236
Port FK / 2002 / Donor characteristics associated with reduced graft survival : an approach to expanding the pool of kidney donors / Transplantation 74:1281~1286
Molnar MZ / 2017 / Predictive score for posttransplantation outcomes / Transplantation 101:1353~1364
Organ Procurement and Transplantation Network (OPTN) / Proposal to substantially revise the national kidney allocation system
Rao PS / 2009 / A comprehensive risk quantification score for deceased donor kidneys the kidney donor risk index / Transplantation 88:231~236
Port FK / 2002 / Donor characteristics associated with reduced graft survival : an approach to expanding the pool of kidney donors / Transplantation 74:1281~1286
Molnar MZ / 2017 / Predictive score for posttransplantation outcomes / Transplantation 101:1353~1364
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