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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 136 - 146 (11page)
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초록· 키워드
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Purpose: This study was aimed to investigate the value of quantitative ultrasound (US) parameters from radiofrequency (RF) data analysis for assessing hepatic steatosis, using controlled attenuation parameter (CAP)-based steatosis grades as the reference standard. Methods: We analyzed 243 participants with both B-mode liver US with RF data acquisition and CAP measurements. On B-mode US images, hepatic steatosis was visually scored (0/1/2/3, none/mild/moderate/severe), and the hepatorenal index (HRI) was calculated. From the RF data analysis, the tissue scatter-distribution imaging parameter (TSI-p) and tissue attenuation imaging parameter (TAI-p) of the liver parenchyma were measured. US parameters were correlated with CAP-based steatosis grades (S0/1/2/3, none/mild/moderate/severe) and their diagnostic performance was evaluated using receiver operating characteristic (ROC) curve analysis. Multivariate linear regression analysis was performed to identify determinants of TSI-p and TAI-p. Results: Participants were classified as having S0 (n=152), S1 (n=54), S2 (n=14), and S3 (n=23) on CAP measurements. TSI-p and TAI-p were significantly correlated with steatosis grades (ρ =0.593 and ρ=-0.617, P<0.001 for both). For predicting ≥S1, ≥S2, and S3, the areas under the ROC curves (AUCs) of TSI-p were 0.827/0.914/0.917; TAI-p, 0.844/0.914/0.909; visual scores, 0.659/0.778/0.794; and HRI, 0.629/0.751/0.759, respectively. TSI-p and TAI-p had significantly higher AUCs than did visual scores or HRI for ≥S1 or ≥S2 (P≤0.003). In the multivariate analysis, the transient elastography-based fibrosis grade (P=0.034) and steatosis grade (P<0.001) were independent determinants of TSI-p, while steatosis grade (P<0.001) was an independent determinant of TAI-p. Conclusion: TSI-p and TAI-p derived from US RF data may be useful for detecting hepatic steatosis and assessing its severity.
목차
등록된 정보가 없습니다.
참고문헌 (40)
참고문헌 신청
Ma X / 2009 / Imaging-based quantification of hepatic fat: methods and clinical applications / Radiographics 29:1253~1277
Wong RJ / 2015 / Nonalcoholic steatohepatitis is the second leading etiology of liver disease among adults awaiting liver transplantation in the United States / Gastroenterology 148:547~555
Veldt BJ / 2008 / Increased risk of hepatocellular carcinoma among patients with hepatitis C cirrhosis and diabetes mellitus / Hepatology 47:1856~1862
Patton HM / 2004 / The impact of steatosis on disease progression and early and sustained treatment response in chronic hepatitis C patients / J Hepatol 40:484~490
Friedman SL / 2018 / Mechanisms of NAFLD development and therapeutic strategies / Nat Med 24:908~922
Wong RJ / 2015 / Nonalcoholic steatohepatitis is the second leading etiology of liver disease among adults awaiting liver transplantation in the United States / Gastroenterology 148:547~555
Veldt BJ / 2008 / Increased risk of hepatocellular carcinoma among patients with hepatitis C cirrhosis and diabetes mellitus / Hepatology 47:1856~1862
Patton HM / 2004 / The impact of steatosis on disease progression and early and sustained treatment response in chronic hepatitis C patients / J Hepatol 40:484~490
Friedman SL / 2018 / Mechanisms of NAFLD development and therapeutic strategies / Nat Med 24:908~922
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