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자료유형
학술저널
저자정보
Dong Wook Kwak (Ajou University) Hyeyeon Boo (Hanyang University College of Medicine) Eun Hye Chang (Areumcheil Women’s Hospital) 류현미 (차의과학대학교 분당차병원) 한유정 (CHA University) Jin Hoon Chung (CHA University) 김문영 (가톨릭관동대학교) Eun Jung Yang (Yonsei University) Hye Ji Yoo (Yonsei University) Jin Woo Kim (Cheil General Hospital and Women's Healthcare Center)
저널정보
대한주산의학회 Perinatology Perinatology Vol.30 No.2
발행연도
2019.1
수록면
78 - 82 (5page)

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Objective: To evaluate the prevalence and distribution of chromosomal defects in Korean fetuses with nuchal translucency (NT) above the 99th percentile and to analyze them according to the degree of NT thickness. Methods: This study retrospectively reviewed the medical records and ultrasonography images of pregnant women whose fetuses were diagnosed with NT ≥3.5 mm at 11 to 14 weeks of gestation and who underwent karyotyping between 2009 and 2015 at Cheil General Hospital, Seoul, Korea. Results: Among 514 fetuses that met the inclusion criteria, 198 (38.5%) fetuses were confirmed as having chromosomal defects. 156 (30.4%) fetuses concerned autosomal aneuploidies, 27 (5.3%) sex-chromosome aneuploidies, and 1 (0.2%) triploidy. Besides, 11 fetuses (2.1%) were identified as pathogenic structural unbalanced chromosome aberration. When the study populations were divided based on NT thickness, 19.8% fetuses with a thickness of 3.5-4.4 mm, 33.0% of 4.5-5.4 mm, 50.3% of 5.5-6.4 mm, and 67.2% of 6.5 mm or more had chromosomal defects. Conclusion: The incidence of chromosomal abnormalities of Korean fetuses with NT thickness above 99th percentile increases with NT thickness, and the prevalence and distribution based on NT thickness were very similar to those of Caucasian fetuses in previous reports.

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