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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 54 - 59 (6page)
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초록· 키워드
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Objective: This study aimed to evaluate the perinatal factors associated with neonatal mortality and neurologic morbidity in term infants with severe acidosis. Methods: We retrospectively reviewed the data of term infants with severe acidosis from January 2012 to December 2016. Severe acidosis was defined as initial pH of less than <7.0 and base excess ≥-12 mmol/L. We searched the clinical characteristics, morbidities of mother and infants, and neuroimaging results. Also infants were divided by neurodevelopmental impairment and evaluated the relating perinatal factors. Results: Twenty three term infants had severe acidosis. Meconium stained amniotic fluid was found in 43.5% and neonatal resuscitation with positive pressure ventilation and endotracheal intubation was needed in 43.5% and 26.1%. Among 8 infants with hypoxic-ischemic encephalopathy (HIE), stage 2 or higher were 87.5%. Four infants (17.4%) showed abnormal brain imaging taken before discharge. On the analysis, the longer duration of invasive mechanical ventilation (P=0.049) and increased need for gavage feeding (P=0.021) were found in neurodevelopment impairment group. Conclusion: The presence of HIE and abnormal findings of brain imaging before discharge were found to be associated with abnormal neurodevelopmental outcome in term infants with severe acidosis. Even if the brain imaging test was normal, we should consider the long-term follow-up of severe acidemic term infants.
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참고문헌 (26)
참고문헌 신청
Ambalavanan N / 2006 / Predicting outcomes of neonates diagnosed with hypoxemic-ischemic encephalopathy / Pediatrics 118:2084~2093
Malin GL / 2010 / Strength of association between umbilical cord pH and perinatal and long term outcomes: systematic review and meta-analysis / BMJ 340:c1471
Randolph DA / 2014 / Outcomes of extremely low birthweight infants with acidosis at birth / Arch Dis Child Fetal Neonatal Ed 99:F263~F268
Yeh P / 2012 / The relationship between umbilical cord arterial pH and serious adverse neonatal outcome: analysis of 51,519 consecutive validated samples / BJOG 119:824~831
Gaudier FL / 1994 / Acid-base status at birth and subsequent neurosensory impairment in surviving 500 to 1000 gm infants / Am J Obstet Gynecol 170:48~53
Malin GL / 2010 / Strength of association between umbilical cord pH and perinatal and long term outcomes: systematic review and meta-analysis / BMJ 340:c1471
Randolph DA / 2014 / Outcomes of extremely low birthweight infants with acidosis at birth / Arch Dis Child Fetal Neonatal Ed 99:F263~F268
Yeh P / 2012 / The relationship between umbilical cord arterial pH and serious adverse neonatal outcome: analysis of 51,519 consecutive validated samples / BJOG 119:824~831
Gaudier FL / 1994 / Acid-base status at birth and subsequent neurosensory impairment in surviving 500 to 1000 gm infants / Am J Obstet Gynecol 170:48~53
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