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자료유형
학술저널
저자정보
Hee Cheol Jo (Department of Pediatrics Ajou University Hospital Ajou University School of Medicine Suwon Korea) Eun Jeong Kim (Department of Pediatrics Ajou University Hospital Ajou University School of Medicine Suwon Korea) Jang Hoon Lee (Department of Pediatrics Ajou University Hospital Ajou University School of Medicine Suwon Korea) Da Eun Jung (Department of Pediatrics Ajou University Hospital Ajou University School of Medicine Suwon Korea) Moon Sung Park (Department of Pediatrics Ajou University Hospital Ajou University School of Medicine Suwon Korea) Sung Hwan Kim (Department of Pediatrics Ajou University Hospital Ajou University School of Medicine Suwon Korea)
저널정보
대한주산의학회 Perinatology Perinatology Vol.26 No.3
발행연도
2015.1
수록면
208 - 214 (7page)

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Purpose: The aims of this study were to estimate the neurodevelopmental outcome of hypoxic-ischemic encephalopathy (HIE) at 12 months, and determine the usefulness of brain magnetic resonance imaging (MRI) and electroencephalography (EEG) to predict neurodevelopmental outcome in term infants with HIE at 12 months. Methods: This study was conducted retrospectively on term infants with HIE from January 2009 to June 2013. Based on neurodevelopmental outcome at 12 months, infants were categorized into 2 groups. Brain MRI and EEG findings were stratified into 4 categories as normal, mild, moderate and severe groups. Results: Total 42 term infants were enrolled. Fifty seven point one percent (24/42) of total infants had favorable neurodevelopmental outcome at 12 months (favorable outcome, n=24). Thirty eight point one percent (16/42) of total infants had significant neurodevelopmental deficit at 12 months of age, and 4.8% (2/42) had mortality within 12 months (poor outcome, n=18). In brain MRI and EEG findings, there were significant correlations with neurodevelopmental outcome. Brain MRI showed sensitivity of 88.9%, specificity of 70.8%, positive predictive value of 69.6% and negative predictive value of 89.5%, while EEG showed sensitivity of 70.6%, specificity of 82.6%, positive predictive value of 75%, and negative predictive value of 79.2%. In the multivariate analysis, moderate-to-severe findings in brain MRI were the strongest risk factor (odds-ratio, 11.24; 95% confidence interval, 1.36-92.89; P =0.025). Conclusion: Forty two point nine percent of total infants had poor neurodevelopmental outcome at 12 months. Brain MRI and EEG findings were correlated with neurodevelopmental outcome of term infants with HIE at 12 months.

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