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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 338 - 349 (12page)
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Background and Objectives: The association of susceptibility loci for atrial fibrillation (AF) with AF recurrence after ablation has been reported, although with controversial results. In this prospective cohort analysis, we aimed to investigate whether a genetic risk score (GRS) can predict the rhythm outcomes after catheter ablation of AF. Methods: We determined the association between 20 AF-susceptible single nucleotide polymorphisms (SNPs) and AF recurrence after catheter ablation in 746 patients (74% males; age, 59±11 years; 56% paroxysmal AF). A GRS was calculated by summing the unweighted numbers of risk alleles of selected SNPs. A Cox proportional hazard model was used to identify the association between the GRS and risk of AF recurrence after catheter ablation. Results: AF recurrences after catheter ablation occurred in 168 (22.5%) subjects with a median follow-up of 23 months. The GRS was calculated using 5 SNPs (rs1448818, rs2200733, rs6843082, rs6838973 at chromosome 4q25 [PITX2] and rs2106261 at chromosome 16q22 [ZFHX3]), which showed modest associations with AF recurrence. The GRS was significantly associated with AF recurrence (hazard ratio [HR] per each score, 1.13; 95% confidence interval [CI], 1.03–1.24). Patients with intermediate (GRS 4–6) and high risks (GRS 7–10) showed HRs of 2.00 (95% CI, 0.99–4.04) and 2.66 (95% CI, 1.32–5.37), respectively, compared to patients with low risk (GRS 0–3). Conclusions: Our novel GRS using 5 AF-susceptible SNPs was strongly associated with AF recurrence after catheter ablation in Korean population, beyond clinical risk factors. Further efforts are warranted to construct a generalizable, robust genetic prediction model which can guide the optimal treatment strategies.
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참고문헌 (30)
참고문헌 신청
Go AS / 2001 / Prevalence of diagnosed atrial fibrillation in adults : national implications for rhythm management and stroke prevention : the AnTicoagulation and Risk Factors in Atrial Fibrillation(ATRIA)study / JAMA 285:2370~2375
Kim MH / 2011 / Estimation of total incremental health care costs in patients with atrial fibrillation in the United States / Circ Cardiovasc Qual Outcomes 4:313~320
Haïssaguerre M / 1998 / Spontaneous initiation of atrial fibrillation by ectopic beats originating in the pulmonary veins / N Engl J Med 339:659~666
January CT / 2014 / 2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation : a report of the American College of Cardiology/American Heart Association Task Force on practice guidelines and the heart rhythm society / J Am Coll Cardiol 64:e1~e76
Sawhney N / 2009 / Five-year outcomes after segmental pulmonary vein isolation for paroxysmal atrial fibrillation / Am J Cardiol 104:366~372
Kim MH / 2011 / Estimation of total incremental health care costs in patients with atrial fibrillation in the United States / Circ Cardiovasc Qual Outcomes 4:313~320
Haïssaguerre M / 1998 / Spontaneous initiation of atrial fibrillation by ectopic beats originating in the pulmonary veins / N Engl J Med 339:659~666
January CT / 2014 / 2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation : a report of the American College of Cardiology/American Heart Association Task Force on practice guidelines and the heart rhythm society / J Am Coll Cardiol 64:e1~e76
Sawhney N / 2009 / Five-year outcomes after segmental pulmonary vein isolation for paroxysmal atrial fibrillation / Am J Cardiol 104:366~372
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