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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 1,244 - 1,250 (7page)
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Purpose: Previous studies have demonstrated an association between eNOS polymorphisms and atrial fibrillation (AF). We sought to determine whether eNOS polymorphisms are associated with AF recurrence after a radiofrequency catheter ablation (RFCA).
Materials and Methods: A total of 500 consecutive patients (56±11 years, 77% male) with paroxysmal (68%) or persistent (32%) AF who underwent RFCA and 500 age, gender-matched controls were genotyped for the eNOS3 single nucleotide polymorphism (rs1799983). AF recurrence was monitored according to 2012 ACC/AHA/ESC guidelines.
Results: The frequencies of the rs1799983 variant alleles (T) in the case and control group were not significantly different (OR 1.05, 95% CI 0.75–1.46, p=0.798). AF patients with rs1799983 variants were more likely to have coronary artery disease or stroke than those without genetic variant at this gene (31.0% vs. 17.3%, p=0.004). During mean 17 months follow-up, early recurrence of AF (ERAF; within 3 months) and clinical recurrence (CR) of AF were 31.8% and 24.8%, respectively. The rs1799983 variant was associatedwith higher risk of ERAF (OR 1.71, 95% CI 1.06–2.79, p=0.028), but not with CR. ERAF occurred earlier (11±16 days) in variant group than those without variant allele (20±25 days, p=0.016). A multiple logistic regression analysis showed that presence of the rs1799983 variant (OR 1.75, 95% CI 1.07–2.86, p=0.026) and persistent AF were independent predictors for ERAF after AF ablation.
Conclusion: The rs1799983 variant of the eNOS3 gene was associated with ERAF, but not with CR, after RFCA. eNOS3 gene variantsmay have a potential role for stratification of post-ablation management.
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참고문헌 (20)
참고문헌 신청
Bedi M / 2006 / Genetic susceptibility to atrial fibrillation in patients with congestive heart failure / Heart Rhythm 3 : 808 ~ 812
Cai H / 2002 / Downregulation of endocardial nitric oxide synthase expression and nitric oxide production in atrial fibrillation: potential mechanisms for atrial thrombosis a
Calkins H / 2012 / 2012 HRS/EHRA/ECAS expert consensus sta
Fatini C / 2006 / Analysis of minK and eNOS genes as candidate loci for predisposition to non-valvular atrial fibrillation / Eur Heart J 27 : 1712 ~ 1718
Fuster V / 2006 / ACC/AHA/ESC 2006 Guidelines for the Management of Patients with Atrial Fibrillation: a report of the American College of Cardiology/American Heart Associati
Cai H / 2002 / Downregulation of endocardial nitric oxide synthase expression and nitric oxide production in atrial fibrillation: potential mechanisms for atrial thrombosis a
Calkins H / 2012 / 2012 HRS/EHRA/ECAS expert consensus sta
Fatini C / 2006 / Analysis of minK and eNOS genes as candidate loci for predisposition to non-valvular atrial fibrillation / Eur Heart J 27 : 1712 ~ 1718
Fuster V / 2006 / ACC/AHA/ESC 2006 Guidelines for the Management of Patients with Atrial Fibrillation: a report of the American College of Cardiology/American Heart Associati
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