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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 429 - 433 (5page)
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초록· 키워드
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Background: Nicardipine, a calcium channel blocker, is used to treat hypertension in pregnancy or preterm labor. The current study was conducted to investigate the relaxant effects of nicardipine on the isolated uterine smooth muscle of the pregnant rat. Methods: We obtained uterine smooth muscle strips from pregnant female SD rats. After uterine contraction with oxytocin 10 mU/ml, we added nicardipine (10−12 to 10−8 M) accumulatively every 20 min. We recorded active tension and frequency of contraction, and calculated EC5 (effective concentration of 5% reduction), EC25, EC50, EC75, and EC95 of active tension and frequency of contraction using a probit model. Results: Nicardipine (10−12 to 10−8 M) decreased active tension and frequency of contraction in a concentration-dependent manner. The EC50 and EC95 of nicardipine in the inhibition of active tension of the uterine smooth muscle were 2.41 × 10−10 M and 3.06 × 10−7 M, respectively. The EC50 and EC95 of nicardipine in the inhibition of frequency of contraction of the uterine smooth muscle were 9.04 × 10−11 and 4.18 × 10−7 M, respectively. Conclusions: Nicardipine relaxed and decreased the frequency of contraction of the uterine smooth muscle in a concentration-dependent pattern. It might be possible to adjust the clinical dosage of nicardipine in the obstetric field based on our results, but further clinical studies are needed to confirm them.
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참고문헌 (15)
참고문헌 신청
Sorkin EM / 1987 / Nicardipine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy, in the treatment of angina pectoris, hypertension and related cardiovascular disorders / Drugs 33:296~345
Nij Bijvank SW / 2010 / Nicardipine for the treatment of severe hypertension in pregnancy : a review of the literature / Obstet Gynecol Surv 65:341~347
Gáspár R / 2013 / Calcium channel blockers as tocolytics:principles of their actions, adverse effects and therapeutic combinations / Pharmaceuticals (Basel) 6:689~699
Wray S / 1993 / Uterine contraction and physiological mechanisms of modulation / Am J Physiol 264(1 Pt 1):C1~C18
Kilkenny C / 2011 / Animal research: reporting in vivo experiments--the ARRIVE guidelines / J Cereb Blood Flow Metab 31:991~993
Nij Bijvank SW / 2010 / Nicardipine for the treatment of severe hypertension in pregnancy : a review of the literature / Obstet Gynecol Surv 65:341~347
Gáspár R / 2013 / Calcium channel blockers as tocolytics:principles of their actions, adverse effects and therapeutic combinations / Pharmaceuticals (Basel) 6:689~699
Wray S / 1993 / Uterine contraction and physiological mechanisms of modulation / Am J Physiol 264(1 Pt 1):C1~C18
Kilkenny C / 2011 / Animal research: reporting in vivo experiments--the ARRIVE guidelines / J Cereb Blood Flow Metab 31:991~993
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