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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 65 - 71 (7page)
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Purpose: We evaluated the oncologic outcomes of organ-preserving strategies in patients with rectal cancer treated with preoperative chemoradiotherapy (PCRT). Methods: Between January 2008 and January 2013, 74 patients who underwent wait-and-watch (WW) (n = 42) and local excision (LE) (n = 32) were enrolled. Organ-preserving strategies were determined based on a combination of magnetic resonance imaging, sigmoidoscopy, and physical examination 4–6 weeks after completion of PCRT. The rectum sparing rate, 5-year recurrence-free survival (RFS), and overall survival (OS) were evaluated. Results: The rectum was more frequently spared in the LE (100% vs. 87.5%, P = 0.018) at last follow-up. Recurrence occurred in 9 (28.1%) WW and 7 (16.7%) LE (P = 0.169). In the WW, 7 patients had only luminal regrowth and 2 had combined lung metastasis. In the LE, 2 (4.8%) had local recurrence only, 4 patients had distant metastasis, and 1 patient had local and distant metastasis. Among 13 patients who indicated salvage surgery (WW, n = 7; LE, n = 11), all in the WW received but all of LE refused salvage surgery (P = 0.048). The 5-year OS and 5-year RFS in overall patients was 92.7% and 76.9%, respectively, and were not different between WW and LE (P = 0.725, P = 0.129). Conclusion: WW and LE were comparable in terms of 5-year OS and RFS. In the LE group, salvage treatment was performed much less among indicated patients. Therefore, methods to improve the oncologic outcomes of patients indicated for salvage treatment should be considered before local excision.
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참고문헌 (25)
참고문헌 신청
Paun BC / 2010 / Postoperative complications following surgery for rectal cancer / Ann Surg 251:807~818
Juul T / 2014 / Low anterior resection syndrome and quality of life : an international multicenter study / Dis Colon Rectum 57:585~591
Fazio VW / 2007 / A randomized multicenter trial to compare long-term functional outcome, quality of life, and complications of surgical procedures for low rectal cancers / Ann Surg 246:481~488
Lange MM / 2008 / Urinary dysfunction after rectal cancer treatment is mainly caused by surgery / Br J Surg 95:1020~1028
Sauer R / 2003 / Adjuvant vs. neoadjuvant radiochemotherapy for locally advanced rectal cancer: the German trial CAO/ARO/AIO-94 / Colorectal Dis 5:406~415
Juul T / 2014 / Low anterior resection syndrome and quality of life : an international multicenter study / Dis Colon Rectum 57:585~591
Fazio VW / 2007 / A randomized multicenter trial to compare long-term functional outcome, quality of life, and complications of surgical procedures for low rectal cancers / Ann Surg 246:481~488
Lange MM / 2008 / Urinary dysfunction after rectal cancer treatment is mainly caused by surgery / Br J Surg 95:1020~1028
Sauer R / 2003 / Adjuvant vs. neoadjuvant radiochemotherapy for locally advanced rectal cancer: the German trial CAO/ARO/AIO-94 / Colorectal Dis 5:406~415
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