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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 312 - 325 (14page)
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초록· 키워드
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In order to evaluate the efficacy and side effects of the non-insulin antidiabetes medications as an adjunct treatment in type 1 diabetes mellitus (T1DM), we conducted systematic searches in MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials for randomized controlled trials published between the date of inception and March 2020 to produce a systematic review and meta-analysis. Overall, 57 studies were included. Compared with placebo, antidiabetes agents in adjunct to insulin treatment resulted in significant reduction in glycosylated hemoglobin (weighted mean difference [WMD], –0.30%; 95% confidence interval [CI], –0.34 to –0.25%; P<0.01) and body weight (WMD, –2.15 kg; 95% CI, –2.77 to –1.53 kg; P<0.01), and required a significantly lower dosage of insulin (WMD, –5.17 unit/day; 95% CI, –6.77 to –3.57 unit/day; P<0.01). Compared with placebo, antidiabetes agents in adjunct to insulin treatment increased the risk of hypoglycemia (relative risk [RR], 1.04; 95% CI, 1.01 to 1.08; P=0.02) and gastrointestinal side effects (RR, 1.99; 95% CI, 1.61 to 2.46; P<0.01) in patients with T1DM. Compared with placebo, the use of non-insulin antidiabetes agents in addition to insulin could lead to glycemic improvement, weight control and lower insulin dosage, while they might be associated with increased risks of hypoglycemia and gastrointestinal side effects in patients with T1DM.
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참고문헌 (34)
참고문헌 신청
Gepts W / 1965 / Pathologic anatomy of the pancreas in juvenile diabetes mellitus / Diabetes 14:619~633
Dinneen S / 1995 / Failure of glucagon suppression contributes to postprandial hyperglycaemia in IDDM / Diabetologia 38:337~343
Muller WA / 1970 / Abnormal alpha-cell function in diabetes : response to carbohydrate and protein ingestion / N Engl J Med 283:109~115
Greenbaum CJ / 2002 / Impaired beta-cell function, incretin effect, and glucagon suppression in patients with type 1 diabetes who have normal fasting glucose / Diabetes 51:951~957
Diabetes Control / 1993 / The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulindependent diabetes mellitus / N Engl J Med 329:977~986
Dinneen S / 1995 / Failure of glucagon suppression contributes to postprandial hyperglycaemia in IDDM / Diabetologia 38:337~343
Muller WA / 1970 / Abnormal alpha-cell function in diabetes : response to carbohydrate and protein ingestion / N Engl J Med 283:109~115
Greenbaum CJ / 2002 / Impaired beta-cell function, incretin effect, and glucagon suppression in patients with type 1 diabetes who have normal fasting glucose / Diabetes 51:951~957
Diabetes Control / 1993 / The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulindependent diabetes mellitus / N Engl J Med 329:977~986
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