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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 291 - 301 (11page)
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Background: Striatin and caveolin-1 (cav-1) are scaffolding/regulating proteins that are associated with salt-sensitive high bloodpressure and promote renal sodium and water reabsorption, respectively. The mineralocorticoid receptor (MR) interacts with striatinand cav-1, while aldosterone increases striatin and cav-1 levels. However, no in vivo data have been reported for the levels of theseproteins in the kidney. Methods: Male Wistar rats were intraperitoneally injected with normal saline solution, aldosterone alone (Aldo: 150 μg/kg bodyweight), or aldosterone after pretreatment with eplerenone, an MR blocker, 30 minutes before the aldosterone injection (eplerenone[Ep.]+Aldo). Thirty minutes after the aldosterone injection, the amount and localization of striatin and cav-1 were determined byWestern blot analysis and immunohistochemistry, respectively. Results: Aldosterone increased striatin levels by 150% (P<0.05), and cav-1 levels by 200% (P<0.001). Eplerenone had no significant effect on striatin levels, but partially blocked the aldosterone-induced increase in cav-1 levels. Aldosterone stimulated striatinand cav-1 immunoreactivity in both the cortex and medulla. Eplerenone reduced cav-1 immunostaining in both areas; however, striatin intensity was reduced in the cortex, but increased in the medulla. Conclusion: This is the first in vivo study demonstrating that aldosterone rapidly enhances renal levels of striatin and cav-1. Aldosterone increases striatin levels via an MR-independent pathway, whereas cav-1 is partially regulated through MR.
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참고문헌 (40)
참고문헌 신청
Hwang J / 2014 / STRIPAK complexes: structure, biological function, and involvement in human diseases / Int J Biochem Cell Biol 47:118~148
Baudrand R / 2014 / Aldosterone’s mechanism of action: roles of lysine-specific demethylase 1, caveolin and striatin / Curr Opin Nephrol Hypertens 23:32~37
Garza AE / 2015 / Variants in striatin gene are associated with salt-sensitive blood pressure in mice and humans / Hypertension 65:211~217
Williere Y / 2018 / Caveolin 1 promotes renal water and salt reabsorption / Sci Rep 8:545
Bollag WB / 2014 / Regulation of aldosterone synthesis and secretion / Compr Physiol 4:1017~1055
Baudrand R / 2014 / Aldosterone’s mechanism of action: roles of lysine-specific demethylase 1, caveolin and striatin / Curr Opin Nephrol Hypertens 23:32~37
Garza AE / 2015 / Variants in striatin gene are associated with salt-sensitive blood pressure in mice and humans / Hypertension 65:211~217
Williere Y / 2018 / Caveolin 1 promotes renal water and salt reabsorption / Sci Rep 8:545
Bollag WB / 2014 / Regulation of aldosterone synthesis and secretion / Compr Physiol 4:1017~1055
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