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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 807 - 814 (8page)
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Background PTX is widely used in cancer treatments. Objective In this paper, we explored the role and potential molecular mechanism of propofol in regulating PTX sensitivity in PC cells. Methods Prostatic cancer cell line PC3 was treated using different concentrations of PTX (10 nM, 50 nM), propofol (150 μM, 300 μM) or transfected with overexpressed HOTAIR plasmid. HOTAIR expression was analyzed by RT-qPCR. Apoptosis of PC3 cells was observed by flow cytometry method while cell viability was evaluated by CCK-8. Moreover, apoptosis-related genes, Bcl-2 and Bax were detected by Western blot methods. E-cadherin, N-cadherin and Vimentin protein concentrations were monitored by ELISA. Results PTX significantly increased apoptosis of PC3 cells and reduced cell viability in a dose-dependent manner. Moreover, Protein expression of Bcl-2 was obviously inhibited while Bax protein expression level was provoked. Furthermore, E-cadherin protein concentration increased while N-cadherin and Vimentin decreased due to increasing PTX treatments. HOTAIR expression dropped due to PTX treatment while overexpression of HOTAIR induced cell viability, EMT and deterred apoptosis. Propofol ignited the PTX function while upregulation of HOTAIR partially reversed this. Conclusion Propofol enhanced paclitaxel sensitivity in prostatic cancer cells through modulation of HOTAIR in vitro.
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참고문헌 (22)
참고문헌 신청
Glen JB / 1985 / Interaction studies and other investigations of the pharmacology of propofol (’Diprivan’) / Postgrad Med J 61(Suppl 3):7~14
Qian J / 2018 / Propofol reversed hypoxiainduced docetaxel resistance in prostate cancer cells by preventing epithelial-mesenchymal transition by inhibiting hypoxia-inducible factor 1α / Biomed Res Int 8:4174232
Rinn JL / 2007 / Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs / Cell 129:1311~1323
Shang Y / 2018 / LncRNA THOR acts as a retinoblastoma promoter through enhancing the combination of c-myc mRNA and IGF2BP1 protein / Biomed Pharmacother 106:1243~1249
Shang Z / 2018 / Propofol promotes apoptosis and suppresses the HOTAIR-mediated mTOR/p70S6K signaling pathway in melanoma cells / Oncol Lett 15:630~634
Qian J / 2018 / Propofol reversed hypoxiainduced docetaxel resistance in prostate cancer cells by preventing epithelial-mesenchymal transition by inhibiting hypoxia-inducible factor 1α / Biomed Res Int 8:4174232
Rinn JL / 2007 / Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs / Cell 129:1311~1323
Shang Y / 2018 / LncRNA THOR acts as a retinoblastoma promoter through enhancing the combination of c-myc mRNA and IGF2BP1 protein / Biomed Pharmacother 106:1243~1249
Shang Z / 2018 / Propofol promotes apoptosis and suppresses the HOTAIR-mediated mTOR/p70S6K signaling pathway in melanoma cells / Oncol Lett 15:630~634
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