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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 417 - 429 (13page)
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Background The mudflat crab Helice tientsinensis is one of the most commercially valuable species for crabmeat production due to its delicious taste. These crabs are mainly found in coastal wetland where they are seriously threatened by toxic heavy metal pollution. In crustaceans, the hepatopancreas is an important organ for detoxification, and metal toxic substances can be converted to non-toxic or less toxic compounds in this organ. Objective To develop a better understanding of the molecular response of H. tientsinensis to the toxic metal cadmium (Cd) and provide a molecular basis for the toxic metal tolerance of H. tientsinensis. Methods In this study, we performed comparative hepatopancreas transcriptome analysis between H. tientsinensis unexposed (as control) and exposed to the toxic metal Cd for 48 h. Results We identified 1089 Cd stress significantly-upregulated and 1560 Cd stress significantly-downregulated unigenes. Functional categorization and annotation of these differentially-expressed genes (DEGs) demonstrated that the response to Cd stress in the hepatopancreas of H. tientsinensis mainly involves “antioxidant activity”, “detoxification”, “toxin degradation activity” and “immune system process”. In addition, five genes (ABCC1, NDUFAF5, ASTL, DES1, CYP27A) were identified as possible major targets for toxic metal tolerance. Conclusion This is the first time reporting that the response of H. tientsinensis to Cd exposure at the transcriptome level, and it lays the foundation for understanding the molecular mechanisms of the response of H. tientsinensis to environmental toxic metal stress.
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참고문헌 (64)
참고문헌 신청
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Almeida EAD / 2007 / Oxidative stress in Perna perna and other bivalves as indicators of environmental stress in the Brazilian marine environment:antioxidants, lipid peroxidation and DNA damage / Comp Biochem Physiol A Mol Integr Physiol 146:588~600
Balaguer P / 2008 / A proposal for boundary delimitation for integrated coastal zone management initiatives / Ocean Coast Manag 51:806~814
Beauchamp E / 2007 / Myristic acid increases the activity of dihydroceramide Delta4-desaturase 1 through its N-terminal myristoylation / Biochimie 89:1553~1561
Bo Y / 2007 / Effects of cadmium on hepatopancreatic antioxidant enzyme activity in freshwater crab Sinopotamon yangtsekiense / Acta Zoologica Sinica :1121~1128
Almeida EAD / 2007 / Oxidative stress in Perna perna and other bivalves as indicators of environmental stress in the Brazilian marine environment:antioxidants, lipid peroxidation and DNA damage / Comp Biochem Physiol A Mol Integr Physiol 146:588~600
Balaguer P / 2008 / A proposal for boundary delimitation for integrated coastal zone management initiatives / Ocean Coast Manag 51:806~814
Beauchamp E / 2007 / Myristic acid increases the activity of dihydroceramide Delta4-desaturase 1 through its N-terminal myristoylation / Biochimie 89:1553~1561
Bo Y / 2007 / Effects of cadmium on hepatopancreatic antioxidant enzyme activity in freshwater crab Sinopotamon yangtsekiense / Acta Zoologica Sinica :1121~1128
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