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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 1 - 11 (11page)
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Background: Disease-specific factors that predispose patients to diverse cardiac diseases in systemic lupus erythematosus (SLE) have been established. The aim of this study was to identify risk factors for cardiac involvement in patients with SLE drawn from the Korean Lupus Network (KORNET) registry. Methods: A total of 437 patients with SLE recruited from the KORNET registry were included in the analysis. The Cox proportional hazard model was used to identify risk factors for the development of cardiac involvement during the follow-up period. The hazard ratios for risk factors of cardiac involvement were assessed using Kaplan-Meier curves and log-rank test. Results: Of 437 patients with SLE, 12 patients (2.7%) developed new cardiac involvement during a median follow-up period of 47.6 months. Frequencies in men and in patients with anti-Sm antibody, anti-Ro antibody, and at least one Systemic Lupus International Collaborating Clinics/American College of Rheumatology damage index (SDI) score in patients with cardiac involvement were higher, compared to those without cardiac involvement (P < 0.001, P = 0.026, P = 0.015, and P < 0.001, respectively). Men gender, older age, anti-Sm antibody, SDI, and corticosteroid dosage were potent predictors for cardiac involvement in patients with SLE in the determination of risk factors for cardiac involvement. Men, anti-Sm antibody positivity, and SDI ≥ 1 increased incidence rates of cardiac involvement for (P < 0.001, P = 0.036, and P < 0.001, respectively). Conclusion: The results of this study reveal that SLE-related factors such as anti-Sm antibody, SDI, and corticosteroid dosage at baseline are risk factors for cardiac involvement in SLE.
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참고문헌 (32)
참고문헌 신청
Lisnevskaia L / 2014 / Systemic lupus erythematosus / Lancet 384(9957):1878~1888
Tsokos GC / 2011 / Systemic lupus erythematosus / N Engl J Med 365(22):2110~2121
Borchers AT / 2004 / Surviving the butterfly and the wolf : mortality trends in systemic lupus erythematosus / Autoimmun Rev 3(6):423~453
Aviña-Zubieta JA / 2017 / Risk of myocardial infarction and stroke in newly diagnosed systemic lupus erythematosus: a general population-based study / Arthritis Care Res (Hoboken) 69(6):849~856
Tselios K / 2017 / Evolution of risk factors for atherosclerotic cardiovascular events in systemic lupus erythematosus : a longterm prospective study / J Rheumatol 44(12):1841~1849
Tsokos GC / 2011 / Systemic lupus erythematosus / N Engl J Med 365(22):2110~2121
Borchers AT / 2004 / Surviving the butterfly and the wolf : mortality trends in systemic lupus erythematosus / Autoimmun Rev 3(6):423~453
Aviña-Zubieta JA / 2017 / Risk of myocardial infarction and stroke in newly diagnosed systemic lupus erythematosus: a general population-based study / Arthritis Care Res (Hoboken) 69(6):849~856
Tselios K / 2017 / Evolution of risk factors for atherosclerotic cardiovascular events in systemic lupus erythematosus : a longterm prospective study / J Rheumatol 44(12):1841~1849
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