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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 1 - 16 (16page)
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Background: We evaluated the effects of neurofeedback as an augmentation treatment on depressive symptoms and functional recovery in patients with treatment-resistant depression (TRD). Methods: We included 24 adult patients with TRD and 12 healthy adults. 24 TRD patients were assigned to the neurofeedback augmentation group (n = 12) and the medication- only (treatment as usual [TAU]) group (n = 12). The neurofeedback augmentation group underwent combined therapy comprising medication and 12–24 sessions of neurofeedback training for 12 weeks. To assess the serum levels of brain-derived neurotrophic factor (BDNF) in both groups, pre- and post-treatment blood samples were obtained. Patients were evaluated using the Hamilton Depression Rating Scale (HAM-D), Beck Depression Inventory (BDI), Clinical Global Impression-Severity (CGI-S), 5-level version of European Quality of Life Questionnaire 5-Dimensional Classification (EQ-5D-5L), and Sheehan Disability Scale (SDS) at baseline, and at the 1-, 4-, and 12-week. Results: From baseline to week 12, neurofeedback training reduced mean scores on HAM-D, BDI-II, CGI-S, and SDS, and increased mean EQ-5D-5L tariff score. In the neurofeedback augmentation group, the response and remission rates were 58.3% and 50.0%, respectively, at week 12. Changes in HAM-D, EQ-5D-5L tariff score, and SDS were significantly larger in the neurofeedback group than in the medication-only (TAU) group. No significant difference in BDNF level was found pre- vs. post-treatment in any of the groups. Conclusion: Despite the small sample size, these results suggest that neurofeedback treatment may be effective as an augmentation treatment, not only for depressive symptoms, but also for functional recovery, in patients with TRD.
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참고문헌 (67)
참고문헌 신청
American Psychiatric Association / 2000 / Diagnostic and Statistical Manual of Mental Disorders: DSM-IV-TR / American Psychiatric Pub
Lépine JP / 2011 / The increasing burden of depression / Neuropsychiatr Dis Treat 7(Suppl 1):3~7
American Psychiatric Association / 2013 / Diagnostic and Statistical Manual of Mental Disorders (DSM-5®) / American Psychiatric Pub
Henderson M / 2011 / Work and common psychiatric disorders / J R Soc Med 104(5):198~207
Crown WH / 2002 / The impact of treatment-resistant depression on health care utilization and costs / J Clin Psychiatry 63(11):963~971
Lépine JP / 2011 / The increasing burden of depression / Neuropsychiatr Dis Treat 7(Suppl 1):3~7
American Psychiatric Association / 2013 / Diagnostic and Statistical Manual of Mental Disorders (DSM-5®) / American Psychiatric Pub
Henderson M / 2011 / Work and common psychiatric disorders / J R Soc Med 104(5):198~207
Crown WH / 2002 / The impact of treatment-resistant depression on health care utilization and costs / J Clin Psychiatry 63(11):963~971
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