지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Treatment-resistant depression (TRD) is a major public health problem. It is estimated that about 30% of patients with major depressive disorder do not show substantial clinical improvement to somatic or psychosocial treatment. Most of studies for TRD have focused on the subjects already known as TRD. Patients with unipolar depressive episodes that do not respond satisfactorily to numerous sequential treatment regimens were included in the TRD studies. Such post hoc experimental design can be regarded only as consequences of having TRD, rather than as causal risk factors for it. Although informative, data derived from such studies often do not allow a distinction to be made between cause and effect. So, we should shift paradigm toward examining the risk for developing TRD in untreated depressed patients. To deal with this problem, untreated depressed patients should be enrolled in the study to identify biological markers for treatment resistance. The peripheral or central biological markers should be explored before starting treatment. Subsequent systematic administration of treatments with appropriate monitoring in the subjects can determine the risk for developing treatment resistance in untreated individuals. Such information could give a cue to improve the initial diagnosis and provide more effective treatment for TRD.
목차
등록된 정보가 없습니다.
참고문헌 (15)
참고문헌 신청
Ruhé HG / 2012 / Staging methods for treatment resistant depression. A systematic review / J Affect Disord 137:35~45
Kim YK / 2016 / The role of pro-inflammatory cytokines in neuroinflammation, neurogenesis and the neuroendocrine system in major depression / Prog Neuropsychopharmacol Biol Psychiatry 64:277~284
Gold PW / 2015 / The organization of the stress system and its dysregulation in depressive illness / Mol Psychiatry 20:32~47
Bauer ME / 2002 / Dexamethasone-induced effects on lymphocyte distribution and expression of adhesion molecules in treatment-resistant depression / Psychiatry Res 113:1~15
Bauer ME / 2003 / Altered glucocorticoid immunoregulation in treatment resistant depression / Psychoneuroendocrinology 28:49~65
Kim YK / 2016 / The role of pro-inflammatory cytokines in neuroinflammation, neurogenesis and the neuroendocrine system in major depression / Prog Neuropsychopharmacol Biol Psychiatry 64:277~284
Gold PW / 2015 / The organization of the stress system and its dysregulation in depressive illness / Mol Psychiatry 20:32~47
Bauer ME / 2002 / Dexamethasone-induced effects on lymphocyte distribution and expression of adhesion molecules in treatment-resistant depression / Psychiatry Res 113:1~15
Bauer ME / 2003 / Altered glucocorticoid immunoregulation in treatment resistant depression / Psychoneuroendocrinology 28:49~65
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