지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Objective. This cross-sectional study aimed to investigate the association between rheumatoid factor (RF) positivity and bone mineral density (BMD) in male Korean subjects without any history of joint disease. Methods. Of 84,344 males who had undergone a comprehensive health checkup program in 2012, 1,390 male health examinees were recruited, whose BMD and RF results were available. A RF titer ≥20 IU/mL was considered positive. BMD was measured at lumbar spine (L1∼L4) or hip (femoral neck and total hip) by dual-energy X-ray absorptiometry. Results. The association between RF positivity and BMD was assessed by multiple linear regression analysis. The mean age was 52.7±10.9 years (range 19∼88 years), and RF was detected in 64 subjects (4.6%). Demographics and laboratory data were not different between RF-positive and -negative subjects except hepatitis B surface antigen (HBsAg), which was more frequently seen in RF-positive subjects (15.6% vs. 4.3%, p=0.001). RF-positive subjects had significantly lower BMD compared to RF-negative subjects in lumbar spine but not in total hip regardless of the existence of HBsAg (1.17±0.16 g/cm2 vs. 1.10±0.18 g/cm2, p=0.002 in total subjects; 1.17±0.16 g/cm2 vs. 1.10±0.18 g/cm2, p=0.004 in HBsAg-negative subjects). After adjusting for multiple confounders, RF positivity was negatively associated with lumbar spine BMD (B=−0.088 and standard error=0.035, p=0.011). Conclusion. Our results show that the presence of RF could have an unfavorable impact on bone density in apparently normal males. Additional studies to elucidate the osteoimmunological mechanism of rheumatoid factor are warranted.
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참고문헌 (35)
참고문헌 신청
Pietschmann P / 2016 / Immunology of osteoporosis: a mini-review / Gerontology 62:128~137
Takayanagi H / 2007 / Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems / Nat Rev Immunol 7:292~304
Franceschi C / 2000 / Inflamm-aging. An evolutionary perspective on immunosenescence / Ann N Y Acad Sci 908:244~254
van der Heijde DM / 1995 / Joint erosions and patients with early rheumatoid arthritis / Br J Rheumatol 34(Suppl 2):74~78
Machold KP / 2007 / Very recent onset rheumatoid arthritis: clinical and serological patient characteristics associated with radiographic progression over the first years of disease / Rheumatology 46:342~349
Takayanagi H / 2007 / Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems / Nat Rev Immunol 7:292~304
Franceschi C / 2000 / Inflamm-aging. An evolutionary perspective on immunosenescence / Ann N Y Acad Sci 908:244~254
van der Heijde DM / 1995 / Joint erosions and patients with early rheumatoid arthritis / Br J Rheumatol 34(Suppl 2):74~78
Machold KP / 2007 / Very recent onset rheumatoid arthritis: clinical and serological patient characteristics associated with radiographic progression over the first years of disease / Rheumatology 46:342~349
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