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논문 기본 정보

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저자정보
Winter Natasha A. (National Health and Medical Research Council Centre for Research Excellence in Severe Asthma and Th) Gibson Peter G. (National Health and Medical Research Council Centre for Research Excellence in Severe Asthma and Th) Fricker Michael (National Health and Medical Research Council Centre for Research Excellence in Severe Asthma and Th) Simpson Jodie L. (School of Medicine and Public Health The University of Newcastle Newcastle NSW Australia.Department) Wark Peter A. (National Health and Medical Research Council Centre for Research Excellence in Severe Asthma and Th) McDonald Vanessa M. (National Health and Medical Research Council Centre for Research Excellence in Severe Asthma and Th)
저널정보
대한천식알레르기학회(구 대한알레르기학회) Allergy, Asthma & Immunology Research Allergy, Asthma & Immunology Research Vol.13 No.3
발행연도
2021.1
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450 - 467 (18page)

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Purpose Systemic inflammatory biomarkers can improve diagnosis and assessment of chronic obstructive pulmonary disease (COPD) and asthma. We aimed to validate an airway disease biomarker panel of 4 systemic inflammatory biomarkers, α2-macroglobulin, ceruloplasmin, haptoglobin and hemopexin, to establish their relationship to airway disease diagnosis and inflammatory phenotypes and to identify an optimized biomarker panel for disease differentiation. Methods Participants with COPD or asthma were classified by inflammatory phenotypes. Immunoassay methods were used to measure levels of validation biomarkers in the sera of participants with disease and non-respiratory disease controls. Markers were analyzed individually and in combination for disease differentiation and compared to established biomarkers (C-reactive protein, interleukin-6, and white blood cell/blood eosinophil count). Results The study population comprised of 141 COPD, 127 severe asthma, 54 mild-moderate asthma and 71 control participants. Significant differences in ceruloplasmin, haptoglobin and hemopexin levels between disease groups and between systemic inflammatory phenotypes were observed. However, no differences were found between airway inflammatory phenotypes. Hemopexin was the best performing individual biomarker and could diagnose COPD versus control participants (area under the curve [AUC], 98.3%; 95% confidence interval [CI], 96.7%–99.9%) and differentiate COPD from asthmatic participants (AUC, 97.0%; 95% CI, 95.4%–98.6%), outperforming established biomarkers. A biomarker panel, including hemopexin, haptoglobin and other established biomarkers, could diagnose asthma versus control participants (AUC, 87.5%; 95% CI, 82.8%–92.2%). Conclusions Hemopexin can be a novel biomarker with superior diagnostic ability in differentiating COPD and asthma. We propose an anti-inflammatory axis between the airways and systemic circulation, in which hemopexin is a protective component in airway disease.
#Asthma #COPD #biomarker #anti-inflammation #hemopexin #haptoglobin #diagnosis #airway inflammation

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참고문헌 (43)

참고문헌 신청
Masoli M / 2004 / Beasley RGlobal Initiative for Asthma (GINA) Program. The global burden of asthma: executive summary of the GINA Dissemination Committee report / Allergy 59:469~478 google schola Lozano R / 2012 / Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010 : a systematic analysis for the Global Burden of Disease Study 2010 / Lancet 380:2095~2128 google schola 송우정 / 2019 / Future Risks in Patients With Severe Asthma / Allergy, Asthma & Immunology Research 11(6):763~778 google schola Simpson JL / 2006 / Inflammatory subtypes in asthma : assessment and identification using induced sputum / Respirology 11:54~61 google schola McDonald VM / 2013 / Multidimensional assessment and tailored interventions for COPD : respiratory utopia or common sense? / Thorax 68:691~694 google schola

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