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논문 기본 정보

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Li Ruyi (Department of Respiratory and Critical Care Medicine Key Laboratory of National Clinical Research C) Wang Feiyun (Innovation Research Institute of Traditional Chinese Medicine Shanghai University of Traditional Ch) Wei Jianghong (Department of Respiratory and Critical Care Medicine Affiliated Hospital of Guilin Medical Universi) Lin Yun (Department of Respiratory and Critical Care Medicine The Second Affiliated Hospital of Guilin Medic) Tang Guofang (Department of Respiratory and Critical Care Medicine Affiliated Hospital of Guilin Medical Universi) Rao Lizong (Laboratory of Pulmonary Diseases Guilin Medical University Guilin China.) Ma Libing (Department of Respiratory and Critical Care Medicine Affiliated Hospital of Guilin Medical Universi) Xu Qing (Department of Respiratory and Critical Care Medicine Affiliated Hospital of Guilin Medical Universi) Wu Jingjie (Department of Respiratory and Critical Care Medicine Affiliated Hospital of Guilin Medical Universi) Lv Qian (Department of Respiratory and Critical Care Medicine Affiliated Hospital of Guilin Medical Universi) Zhou Rui (Department of Respiratory and Critical Care Medicine The Second Xiangya Hospital Changsha China.) Lei Huiren (Laboratory of Pulmonary Diseases Guilin Medical University Guilin China.) Zhao Xueqiang (Department of Respiratory and Critical Care Medicine The Second Affiliated Hospital of Guilin Medic) Yao Dong (Laboratory of Pulmonary Diseases Guilin Medical University Guilin China.) Xiao Bo (Laboratory of Pulmonary Diseases Guilin Medical University Guilin China.) Huang Haiming (Laboratory of Pulmonary Diseases Guilin Medical University Guilin China.) Zhang Jiange (Innovation Research Institute of Traditional Chinese Medicine Shanghai University of Traditional Ch) Mo Biwen (Department of Respiratory and Critical Care Medicine The Second Affiliated Hospital of Guilin Medic)
저널정보
대한천식알레르기학회(구 대한알레르기학회) Allergy, Asthma & Immunology Research Allergy, Asthma & Immunology Research Vol.13 No.1
발행연도
2021.1
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88 - 105 (18page)

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Purpose: Recent studies have demonstrated that macrophage migration inhibitory factor (MIF) is of importance in asthmatic inflammation. The role of MIF in modulating airway remodeling has not yet been thoroughly elucidated to date. In the present study, we hypothesized that MIF promoted airway remodeling by intensifying airway smooth muscle cell (ASMC) autophagy and explored the specific mechanisms. Methods: MIF knockdown in the lung tissues of C57BL/6 mice was conducted by instilling intratracheally adeno-associated virus (AAV) vectors (MIF-mutant AAV9) into mouse lung tissues. Mice genetically deficient in the autophagy marker ATG5 (ATG5+/−) was used to detect the role of autophagy in ovalbumin (OVA)-asthmatic murine models. Moreover, to block the expression of MIF and CD74 in vitro models, inhibitors, antibodies and lentivirus transfection techniques were employed. Results: First, MIF knockdown in the lung tissues of mice showed markedly reduced airway remodeling in OVA murine mice models. Secondly, ASMC autophagy was increased in the OVA-challenged models. Mice genetically deficient in the autophagy marker ATG5 (ATG5+/−) that were primed and challenged with OVA showed lower airway remodeling than genetically wild-type asthmatic mice. Thirdly, MIF can induce ASMC autophagy in vitro. Moreover, the cellular source of MIF which promoted ASMC autophagy was macrophages. Finally, MIF promoted ASMC autophagy in a CD74-dependent manner. Conclusions: MIF can increase asthmatic airway remodeling by enhancing ASMC autophagy. Macrophage-derived MIF can promote ASMC autophagy by targeting CD74.
#Macrophage migration inhibitory factor #airway remodeling #autophagy #Smooth muscle

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참고문헌 신청
Vos T / 2012 / Years lived with disability(YLDs)for 1160 sequelae of 289 diseases and injuries 1990–2010 : a systematic analysis for the Global Burden of Disease Study 2010 / Lancet 380:2163~2196 google schola Hamid Q / 2003 / Inflammatory cells in asthma: mechanisms and implications for therapy / J Allergy Clin Immunol 111:S5~S12 google schola Holgate ST / 2002 / Asthma : more than an inflammatory disease / Curr Opin Allergy Clin Immunol 2:27~29 google schola Hogg JC / 1997 / The pathology of asthma / APMIS 105:735~745 google schola Busse WW / 2000 / Pathophysiology of severe asthma / J Allergy Clin Immunol 106:1033~1042 google schola

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