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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 454 - 461 (8page)
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초록· 키워드
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Background: Despite evidence from animal and clinical studies showing the detrimental effects of macrophage migration inhibitoryfactor (MIF) on bone metabolism, there are no clinical studies relating circulating MIF levels to osteoporosis-related phenotypes. This cross-sectional study investigated the association of plasma MIF with bone mineral density (BMD), bone turnovermarkers (BTMs), and prevalence of osteoporosis in postmenopausal Korean women. Methods: A total of 246 women not taking any medications or diagnosed with any diseases that could affect bone metabolismwere enrolled. BMD values at the lumbar spine, femoral neck, and total femur, and blood levels of MIF and BTMs were measuredin all subjects. Osteoporosis was defined by World Health Organization criteria. Results: Before and after adjustment for confounding variables, higher MIF levels were significantly associated with lower BMDvalues at all measured sites and higher levels of all BTMs. All BMD values and BTMs significantly changed in a dose-dependentfashion across increasing MIF quartile. When participants were divided into two groups according to osteoporosis status, postmenopausalwomen with osteoporosis demonstrated 24.2% higher plasma MIF levels than those without osteoporosis (P=0.041). The odds ratio per each standard deviation increment of MIF levels for prevalent osteoporosis was 1.32 (95% confidence interval,1.01 to 1.73). Conclusion: This study provides the first epidemiological evidence that higher plasma MIF may be associated with higher risk ofosteoporosis resulting from lower bone mass and higher bone turnover rate, and thus it could be a potential biomarker of poorbone health outcomes in postmenopausal women.
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참고문헌 (23)
참고문헌 신청
Hattner R / 1965 / Suggested sequential mode of control of changes in cell behaviour in adult bone remodelling / Nature 206:489~490
시먼에고 / 2015 / Growth and Age-Related Abnormalities in Cortical Structure and Fracture Risk / Endocrinology and Metabolism 30(4):419~428
이영균 / 2013 / Epidemiology of Osteoporosis and Osteoporotic Fractures in South Korea / Endocrinology and Metabolism 28(2):90~93
Bucala R / 2014 / The integral role of CD74 in antigen presentation, MIF signal transduction, and B cell survival and homeostasis / Mini Rev Med Chem 14:1132~1138
김봉성 / 2015 / The macrophage migration inhibitory factor protein superfamily in obesity and wound repair / Experimental and Molecular Medicine 47:1~10
시먼에고 / 2015 / Growth and Age-Related Abnormalities in Cortical Structure and Fracture Risk / Endocrinology and Metabolism 30(4):419~428
이영균 / 2013 / Epidemiology of Osteoporosis and Osteoporotic Fractures in South Korea / Endocrinology and Metabolism 28(2):90~93
Bucala R / 2014 / The integral role of CD74 in antigen presentation, MIF signal transduction, and B cell survival and homeostasis / Mini Rev Med Chem 14:1132~1138
김봉성 / 2015 / The macrophage migration inhibitory factor protein superfamily in obesity and wound repair / Experimental and Molecular Medicine 47:1~10
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