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논문 기본 정보

자료유형
학술저널
저자정보
Young-jin Lee (Division of Breast Surgery Department of Surgery Asan Medical Center University of Ulsan College) Zhen-Yu Wu (Division of Breast Surgery Department of Surgery Asan Medical Center University of Ulsan College) Hee jeong Kim (Division of Breast Surgery Department of Surgery Asan Medical Center University of Ulsan College) Jong Won Lee (Division of Breast Surgery Department of Surgery Asan Medical Center University of Ulsan College) Il Yong Chung (Division of Breast Surgery Department of Surgery Asan Medical Center University of Ulsan College) Jisun Kim (Division of Breast Surgery Department of Surgery Asan Medical Center University of Ulsan College) Sae Byul Lee (Division of Breast Surgery Department of Surgery Asan Medical Center University of Ulsan College) 손병호 (울산대학교) Sung-Bae Kim (Department of Oncology Asan Medical Center University of Ulsan College of Medicine Seoul Korea) Jae Ho Jung (Department of Oncology Asan Medical Center University of Ulsan College of Medicine Seoul Korea) Gyungyub Gong (Department of Pathology Asan Medical Center University of Ulsan College of Medicine Seoul Korea) Sei-Hyun Ahn (Division of Breast Surgery Department of Surgery Asan Medical Center University of Ulsan College) 고범석 (서울아산병원)
저널정보
한국유방암학회 Journal of Breast Cancer Journal of Breast Cancer Vol.23 No.5
발행연도
2020.1
수록면
553 - 559 (7page)

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The combination of luteinizing hormone-releasing hormone analogs (LHRHa) with tamoxifen is used as a standard postoperative adjuvant therapy in patients with hormone receptor-positive/premenopausal breast cancer. Long-acting LHRHa formulations offer advantages in terms of patient convenience. However, data on the effectiveness of the 3-month (3M) acting formulation are still insufficient. This study was performed on patients who received the 3M LHRHa after surgery. The serum estradiol (E2) and follicle-stimulating hormone levels were measured before surgery, and periodically after surgery. In total, 318 patients were included in the study and analyzed. The mean E2 level before surgery was 63.7 pg/mL, while the mean E2 level during the administration of 3M LHRHa was 4.9 pg/mL. None of the patients were menstruating and had E2 values above 30.0 pg/mL. It is thought that the 3M LHRHa formulation can suppress the ovarian function effectively and be safely used to improve compliance.
#Breast neoplasms #Premenopaus #Antineoplastic agents #Gonadotropin-releasing hormone

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참고문헌 신청
강상율 / 2018 / Basic Findings Regarding Breast Cancer in Korea in 2015: Data from a Breast Cancer Registry / Journal of Breast Cancer 21(1):1~10 dbpia Burstein HJ / 2019 / Adjuvant endocrine therapy for women with hormone receptor-positive breast cancer : ASCO clinical practice guideline focused update / J Clin Oncol 37:423~438 google schola Balic M / 2019 / Gallen/Vienna 2019: a brief summary of the consensus discussion on the optimal primary breast cancer treatment / Breast Care(Basel) 14:103~110 google schola Swarm RA / 2019 / NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®). Adult Cancer Pain Version / National Comprehensive Cancer Network google schola 박우찬 / 2016 / Role of Ovarian Function Suppression in Premenopausal Women with Early Breast Cancer / Journal of Breast Cancer 19(4):341~348 dbpia

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