Hormone Receptor Expression and Clinicopathologic Features in Male and Female Breast Cancer

Shandiz, Fatemeh Homaei; Tavassoli, Aliraz; Sharifi, Nourieh; Khales, Sima Ardalan; Kadkhodayan, Sima; Khales, Sahar Ardalan

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자료유형: 학술저널

저자정보: Shandiz, Fatemeh Homaei (Radiation-Oncology, Solid Tumor Treatment Research Center, Mashhad University of Medical Sciences) Tavassoli, Aliraz (Surgery, Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences) Sharifi, Nourieh (Pathology, Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences) Khales, Sima Ardalan (Division of Human Genetics, Immunology Research Center, Avicenna Research Institute, Mashhad University of Medical Sciences) Kadkhodayan, Sima (Gynecology Oncology, Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences) Khales, Sahar Ardalan (Department of Modern Sciences and Technologies, School of Medicine, Mashhad University of Medical Sciences)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제2호

발행연도: 2015.1

수록면: 471 - 474 (4page)

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Background: Male and female breast cancers were investigated for variation in the clinicopathologic characteristics and expression of steroid hormone receptors in the northeast of Iran. Materials and Methods: Tumor specimens of 17 males and 338 females with breast cancer were collected at the hospitals of Mashhad University of Medical Sciences. Immunohistochemical expression of hormone receptors and clinicopathologic features of breast cancer were compared between two groups. Results: The mean age in men was 15 years higher than women (p=0.000). Males and females were mainly in stage II and III respectively (p=0.007). Although more than 60% of male and female patients were grade II, the respective figures for grade I and III were 25% and 12.5% in men but 7.1% and 27.2% in women respectively (p=0.025). ER was significantly more positive in men against women; 82.3% versus 53.4% (p=0.016). The related measures for PR was 58.8% and 50.3%, respectively (p=0.424). Males also showed significantly more ER expression than postmenopausal females; 82.3% versus 48.9% (p=0.010). Conclusions: Breast cancer in males and females contrasted in age at diagnosis, histological type, stage, grade and ER expression which emphasize they are separate diseases with different behaviors.

#Male #female #breast carcinoma #steroid receptor #stage #Iran

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Shandiz, Fatemeh Homaei

소속기관 Department of Radiotherapy-Oncology, Omid and Ghaem Hospitals, Mashhad University of Medical Science