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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.10
- 수록면
- 304 - 304 (1page)
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Iron is an essential element for survival and metabolism for all living organisms including archaea, bacteria, and mammals. Each has evolved specialized iron uptake systems to efficiently acquire iron from the extracellular environment, competing each other for the vital nutrient. As the mammalian hosts sequester iron providing an innate defense, termed nutritional immunity, pathogenic microorganisms also have developed a number of ways to acquire, transport, and store iron for survival and virulence expression within their hosts. Especially the bacterial ferrous iron transporter protein FeoB functions as a major iron transporter in prokaryotes, making it a potential target for anti-microbial and anti-virulence therapeutics. In order to develop a novel class of anti-microbial agents targeting the bacterial iron metabolism, high throughput screening of inhibitors against the nucleotide hydrolysis activity of FeoB ba ... 전체 초록 보기
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