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논문 기본 정보

자료유형
학술저널
저자정보
Yoon Hyuk (Department of Internal Medicine Seoul National University Bundang Hospital Seongnam Korea) Lee Dong Ho (Department of Internal Medicine Seoul National University Bundang Hospital Seongnam Korea) Lee Je Hee (ChunLab Inc. Seoul Korea) Kwon Ji Eun (Armed Forces Capital Hospital Seongnam Korea) Shin Cheol Min (Department of Internal Medicine Seoul National University Bundang Hospital Seongnam Korea) Yang Seung-Jo (ChunLab Inc. Seoul Korea) Park Seung-Hwan (Korean Collection for Type Cultures Biological Resource Center Korea Research Institute of Bioscien) Lee Ju Huck (Korean Collection for Type Cultures Biological Resource Center Korea Research Institute of Bioscien) Kang Se Won (Korean Collection for Type Cultures Biological Resource Center Korea Research Institute of Bioscien) Lee Jung-Sook (Korean Collection for Type Cultures Biological Resource Center Korea Research Institute of Bioscien) Kim Byung-Yong (ChunLab Inc. Seoul Korea)
저널정보
거트앤리버 발행위원회 Gut and Liver Gut and Liver 제15권 제2호
발행연도
2021.1
수록면
243 - 252 (10page)

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Background/Aims: South Korean soldiers are exposed to similar environmental factors. In this study, we sought to evaluate the gut microbiome of healthy young male soldiers (HYMS) and to identify the primary factors influencing the microbiome composition. Methods: We prospectively collected stool from 100 HYMS and performed next-generation sequencing of the 16S rRNA genes of fecal bacteria. Clinical data, including data relating to the diet, smoking, drinking, and exercise, were collected. Results: The relative abundances of the bacterial phyla Firmicutes, Actinobacteria, Bacteroidetes, and Proteobacteria were 72.3%, 14.5%, 8.9%, and 4.0%, respectively. Fifteen species, most of which belonged to Firmicutes (87%), were detected in all examined subjects. Using cluster analysis, we found that the subjects could be divided into the two enterotypes based on the gut microbiome bacterial composition. Compared with enterotype 2 subjects, subjects classified as enterotype 1 tended to be characterized by higher frequencies of potentially harmful lifestyle habits (current smoker: 55.6% vs 36.6%, p=0.222; heavy drinker: 16.7% vs 3.7%, p=0.120; insufficient physical activity: 27.8% vs 14.6%, p=0.318). We identified a significant difference in the microbiome compositions of current and noncurrent smokers (p=0.008); the former differed from the latter mainly in a relatively lower abundance of Bifidobacterium species and a higher abundance of Negativicutes. Conclusions: A high abundance of Actinobacteria and low abundance of Bacteroidetes were the main features distinguishing the gut microbiomes of HYMS, and current smokers could be differentiated from noncurrent smokers by their lower abundance of Bifidobacterium and higher abundance of Negativicutes.

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