Effect of Smoking on Retinal Thickness and Vascular Density in Thyroid Eye Disease

Mansooreh Jamshidian-Tehrani; Abolfazl Kasaei; Zahra Mahdizad; Masoud Aghsaei Fard; Mehdi Aminizade

doi:10.3341/kjo.2021.0059

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저자정보: Mansooreh Jamshidian-Tehrani (Tehran University of Medical Sciences) Abolfazl Kasaei (Tehran University of Medical Sciences) Zahra Mahdizad (Tehran University of Medical Sciences) Masoud Aghsaei Fard (Tehran University of Medical Sciences) Mehdi Aminizade (Tehran University of Medical Sciences)

저널정보: 대한안과학회 Korean Journal of Ophthalmology Korean Journal of Ophthalmology 제35권 제5호

발행연도: 2021.10

수록면: 376 - 382 (7page)

DOI: 10.3341/kjo.2021.0059

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Purpose: To evaluate the effect of smoking on retinal thickness and macular and peripapillary vascular density in thyroid eyedisease (TED). Methods: In this cross-sectional study, subjects diagnosed with TED were analyzed in three groups: smokers, passive smokers,and non-smokers. Ganglion cell complex thickness, total retinal thickness, macular superficial vascular plexus densities,deep vascular plexus densities, optic nerve head, and radial peripapillary capillary density were measured in each group. Results: Twenty-two eyes (21.6%) of active smokers, 11 eyes (10.8%) of passive smokers, and 69 eyes (67.6%) of non-smokersconstitute the study subjects. Twenty-one eyes (12.6%) had active status (clinical activity score ≥3), 77 eyes (46.1%) wereneither active nor compressive, four eyes (2.4%) of two patients constituted the compressive group. Age and disease activityadjusted analysis was performed. Ganglion cell complex thickness of smokers was significantly higher than non-smokers inthe inferior hemi-parafoveal sector (p = 0.04). Active smokers had significantly higher (p < 0.01) retinal thickness in all sectorscompared to non-smokers, except the foveal sector. Smokers had lower superficial vessel density in the superior parafovealsector compared to non-smokers (p = 0.04). Considering deep vessel densities between smokers and non-smokers, no significantdifference was observed. Radial peripapillary capillary densities (significant difference was observed in the whole imageand infranasal peripapillary sector), Macular vascular densities (significant difference was observed in parafoveal sectors), andoptic nerve head (not reaching statistical significance level in any sectors) were highest in passive smokers. Conclusions: Smoking is associated with increased total retinal thickness. Macular vascular densities were not different betweensmokers and non-smokers in TED.

#Graves ophthalmopathy #Retinal diseases #Smoking

참고문헌 (23)

참고문헌 신청

Weiler DL / 2017 / Thyroid eye disease: a review / Clin Exp Optom 100:20~25

Lewis KT / 2019 / Changes in peripapillary blood vessel density in Graves’ orbitopathy after orbital decompression surgery as measured by optical coherence tomography angiography / Orbit 38:87~94

Khong JJ / 2016 / Risk factors for Graves’ orbitopathy; the Australian thyroid-associated orbitopathy research (ATOR) study / J Clin Endocrinol Metab 101:2711~2720

Jamshidian Tehrani M / 2019 / Early macular and peripapillary vasculature dropout in active thyroid eye disease / Graefes Arch Clin Exp Ophthalmol 257:2533~2540

Sadeghi-Tari A / 2017 / Reply to: ‘Comment on: effect of smoking on retrobulbar blood flow in thyroid eye disease’ / Eye (Lond) 31:814~815

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