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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
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Mycobacterium tuberculosis (M.TB) infection in human immunodeficiency virus (HIV)-infected patients is one of the major opportunistic diseases, leading to severe morbidity and mortality. According to World Health Organization (WHO) tuberculosis (TB) reports,1 the number of patients with TB-HIV coinfection was 900,000 and the number of deaths was 300,000 in 2017. Comparing to the mortality rate of 16% due to TB in the general population, the percentage of deaths in TB-HIV patients was double at 33%. However, it is not easy to manage TB in immunocompromised hosts due to variable reasons: 1) vague symptoms related with TB, 2) low yields for microbiologic tests, 3) nontypical radiologic findings, 4) drug-drug interaction between anti-TB and anti-retroviral therapy (ART), 5) immune reconstitution inflammatory syndrome during the treatment, most of which are hurdles related with diagnosis. Therefore, the best strategy is to confirm and treat latent TB infection (LTBI), an early stage of TB infection that is characterized by a status of persistent immunity to M.TB antigen without manifestations of active disease, in HIV patients. Recently, WHO guidelines for LTBI2 also recommend that for adults living with HIV, LTBI should be treated in cases with unknown or a positive tuberculin skin test (TST) and without the evidence of active TB, irrespective of regional TB prevalence, the degree of immunosuppression, and use of ART
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참고문헌 (8)
참고문헌 신청
WHO global tuberculosis report 2018
WHO latent tuberculosis infection: updated and consolidated guidelines for programmatic management
Sharma SK / 2017 / Comparison of TST and IGRA in diagnosis of latent tuberculosis infection in a high TB-burden setting / PLoS One 12(1):e0169539
Chkhartishvili N / 2013 / Poor agreement between interferon-gamma release assays and the tuberculin skin test among HIV-infected individuals in the country of Georgia / BMC Infect Dis 13(513):513
Reviono Reviono / 2019 / Good Agreement between an Interferon Gamma Release Assay and Tuberculin Skin Tests in Testing for Latent Tuberculosis Infection among HIV-Infected Patients in Indonesia / Journal of Korean Medical Science 34(40):1~10
WHO latent tuberculosis infection: updated and consolidated guidelines for programmatic management
Sharma SK / 2017 / Comparison of TST and IGRA in diagnosis of latent tuberculosis infection in a high TB-burden setting / PLoS One 12(1):e0169539
Chkhartishvili N / 2013 / Poor agreement between interferon-gamma release assays and the tuberculin skin test among HIV-infected individuals in the country of Georgia / BMC Infect Dis 13(513):513
Reviono Reviono / 2019 / Good Agreement between an Interferon Gamma Release Assay and Tuberculin Skin Tests in Testing for Latent Tuberculosis Infection among HIV-Infected Patients in Indonesia / Journal of Korean Medical Science 34(40):1~10
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