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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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OBJECTIVES This study aimed to explore whether common genetic variants that confer the risk of schizophrenia have similar effects between Korean and European ancestries using the polygenic risk score (PRS) analysis. METHODS Study subjects included 713 Korean patients with schizophrenia and 497 healthy controls. The Korea Biobank array was used for genotyping. Summary statistics of the most recent genome-wide association study (GWAS) of the European population were used as baseline data to calculate PRS. Logistic regression was conducted to determine the association between calculated PRS of European patients with schizophrenia and clinical diagnosis of schizophrenia in the Korean population. RESULTS Schizophrenia PRS was significantly higher in patients with schizophrenia than in healthy controls. The PRS at the pvalue threshold of 0.5 best explained the variance of schizophrenia (R2=0.028, p=4.4×10-6). The association was significant after adjusting for age and sex (odds ratio=1.34, 95% confidence interval=1.19-1.51, p=1.1×10?6). The pattern of the association remained similar across different p-value thresholds (0.01-1). CONCLUSION Schizophrenia PRS calculated using the European GWAS data showed a significant association with the clinical diagnosis of schizophrenia in the Korean population. Results suggest overlapping genetic risk variants between the two populations.
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참고문헌 (39)
참고문헌 신청
Stilo SA / 2010 / The epidemiology of schizophrenia : replacing dogma with knowledge / Dialogues Clin Neurosci 12:305~315
Flint J / 2014 / Schizophrenia : genesis of a complex disease / Nature 511:412~413
Cardno AG / 2000 / Twin studies of schizophrenia : from bowand-arrow concordances to star wars Mx and functional genomics / Am J Med Genet 97:12~17
Sullivan PF / 2003 / Schizophrenia as a complex trait : evidence from a meta-analysis of twin studies / Arch Gen Psychiatry 60:1187~1192
Burmeister M / 2008 / Psychiatric genetics : progress amid controversy / Nat Rev Genet 9:527~540
Flint J / 2014 / Schizophrenia : genesis of a complex disease / Nature 511:412~413
Cardno AG / 2000 / Twin studies of schizophrenia : from bowand-arrow concordances to star wars Mx and functional genomics / Am J Med Genet 97:12~17
Sullivan PF / 2003 / Schizophrenia as a complex trait : evidence from a meta-analysis of twin studies / Arch Gen Psychiatry 60:1187~1192
Burmeister M / 2008 / Psychiatric genetics : progress amid controversy / Nat Rev Genet 9:527~540
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