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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제51권 제2호
- 발행연도
- 2017.1
- 수록면
- 148 - 151 (4page)
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Background: Pityriasis rosea (PR) is a common papulosquamous skin disease in which an infective agent may be implicated. Toll-like receptors (TLRs) play an important role in immune responses and in the pathophysiology of inflammatory skin diseases. Our aim was to determine the possible roles of TLRs 3, 7, 8, and 9 in the pathogenesis of PR. Methods: Twenty-four PR patients and 24 healthy individuals (as controls) were included in this case control study. All recruits were subjected to routine laboratory investigations. Biopsies were obtained from one active PR lesion and from healthy skin of controls for the detection of TLR 3, 7, 8, and 9 gene expression using real-time polymerase chain reaction. Results: This study included 24 patients (8 females and 16 males) with active PR lesions, with a mean age of 28.62 years. Twenty four healthy age- and sex-matched individuals were included as controls (8 females and 16 males, with a mean age of 30.83 years). The results of the routine laboratory tests revealed no significant differences between both groups. Significantly elevated expression of all studied TLRs were detected in PR patients relative to healthy controls (p < .001). Conclusions: TLRs 3, 7, 8, and 9 might be involved in the pathogenesis of PR.
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참고문헌 (15)
참고문헌 신청
Ataseven A / 2014 / Unilateral pityriasis rosea / Indian Dermatol Online J 5 : 528 ~ 529
Broccolo F / 2005 / Additional evidence that pityriasis rosea is associated with reactivation of human herpesvirus-6 and-7 / J Invest Dermatol 124 : 1234 ~ 1240
Carty M / 2010 / Recent insights into the role of Toll-like receptors in viral infection / Clin Exp Immunol 161 : 397 ~ 406
Chuh A / 2004 / Pityriasis rosea: evidence for and against an infectious aetiology / Epidemiol Infect 132 : 381 ~ 390
Drago F / 2006 / Use of high-dose acyclovir in pityriasis rosea / J Am Acad Dermatol 54 : 82 ~ 85
Broccolo F / 2005 / Additional evidence that pityriasis rosea is associated with reactivation of human herpesvirus-6 and-7 / J Invest Dermatol 124 : 1234 ~ 1240
Carty M / 2010 / Recent insights into the role of Toll-like receptors in viral infection / Clin Exp Immunol 161 : 397 ~ 406
Chuh A / 2004 / Pityriasis rosea: evidence for and against an infectious aetiology / Epidemiol Infect 132 : 381 ~ 390
Drago F / 2006 / Use of high-dose acyclovir in pityriasis rosea / J Am Acad Dermatol 54 : 82 ~ 85
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