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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 255 - 261 (7page)
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초록· 키워드
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Purpose: This study aimed to examine the inter-method reliability and volumetric differences between NeuroQuant (NQ) and Freesurfer (FS) using T1 volume imaging sequence with different slice thicknesses in patients with mild cognitive impairment (MCI). Materials and Methods: This retrospective study enrolled 80 patients diagnosed with MCI at our memory clinic. NQ and FS were used for volumetric analysis of three-dimensional T1-weighted images with slice thickness of 1 and 1.2 mm. Inter-method reliability was measured with Pearson correlation coefficient (r), intraclass correlation coefficient (ICC), and effect size (ES). Results: Overall, NQ volumes were larger than FS volumes in several locations: whole brain (0.78%), cortical gray matter (5.34%), and white matter (2.68%). Volume measures by NQ and FS showed good-to-excellent ICCs with both 1 and 1.2 mm slice thickness (ICC=0.75?0.97, ES=-1.0?0.73 vs. ICC=0.78?0.96, ES=-0.9?0.77, respectively), except for putamen, pallidum, thalamus, and total intracranial volumes. The ICCs in all locations, except the putamen and cerebellum, were slightly higher with a slice thickness of 1 mm compared to those of 1.2 mm. Conclusion: Inter-method reliability between NQ and FS was good-to-excellent in most regions with improvement with a 1-mm slice thickness. This finding indicates that the potential effects of slice thickness should be considered when performing volumetric measurements for cognitive impairment.
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참고문헌 (27)
참고문헌 신청
Brewer JB / 2009 / Fully-automated quantification of regional brain volumes for improved detection of focal atrophy in Alzheimer disease / AJNR Am J Neuroradiol 30:578~580
Braak H / 1991 / Neuropathological stageing of Alzheimer-related changes / Acta Neuropathol 82:239~259
Jack CR Jr / 1997 / Medial temporal atrophy on MRI in normal aging and very mild Alzheimer’s disease / Neurology 49:786~794
박미나 / 2016 / Structural MR Imaging in the Diagnosis of Alzheimer’s Disease and Other Neurodegenerative Dementia: Current Imaging Approach and Future Perspectives / Korean Journal of Radiology 17(6):827~845
Min J / 2017 / Diagnostic efficacy of structural MRI in patients with mild-to-moderate Alzheimer disease : automated volumetric assessment versus visual assessment / AJR Am J Roentgenol 208:617~623
Braak H / 1991 / Neuropathological stageing of Alzheimer-related changes / Acta Neuropathol 82:239~259
Jack CR Jr / 1997 / Medial temporal atrophy on MRI in normal aging and very mild Alzheimer’s disease / Neurology 49:786~794
박미나 / 2016 / Structural MR Imaging in the Diagnosis of Alzheimer’s Disease and Other Neurodegenerative Dementia: Current Imaging Approach and Future Perspectives / Korean Journal of Radiology 17(6):827~845
Min J / 2017 / Diagnostic efficacy of structural MRI in patients with mild-to-moderate Alzheimer disease : automated volumetric assessment versus visual assessment / AJR Am J Roentgenol 208:617~623
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