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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 860 - 867 (8page)
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초록· 키워드
오류제보하기
Purpose: Non-alcoholic fatty liver disease (NAFLD) is independently associated with the development of atrial fibrillation (AF). However, the association of AF with advanced liver fibrosis, which is related to all-cause, cardiovascular, and liver-related mortality, has not been established in NAFLD patients. We aimed to investigate the association between AF and advanced liver fibrosis in NAFLD patients. Materials and Methods: Out of 53704 adults who participated in the health check-up program, 6293 subjects aged 35 years and older were diagnosed as NAFLD using ultrasound. The stage of liver fibrosis was assessed based on the newly adjusted NAFLD fibrosis score (NFS) and Fibrosis-4 (Fib-4) Index, which were used to determine the low and high cut-off values (COVs). Results: Of 6293 patients with NAFLD, 59 (0.9%) were diagnosed with AF. Patients with AF were older (52.0 vs. 64.6 years, p<0.001), had higher body mass index (25.2 vs. 26.6 kg/m2, p<0.001), and had bigger waist circumference (84.0 vs. 89.9 cm, p<0.001) than those without AF. In NAFLD patients, AF was independently associated with advanced liver fibrosis, assessed using both COVs of NFS [low-COV group: final adjusted odds ratios (aORs)=2.85, p=0.004; high-COV group: ORs=12.29, p<0.001). AF was independently associated with advanced liver fibrosis, assessed using both COVs of Fib-4 (low-COV group: aORs=2.49, p<0.001; high-COV group: aORs=3.84, p=0.016). Conclusion: AF is independently associated with advanced liver fibrosis in patients with NAFLD.
목차
등록된 정보가 없습니다.
참고문헌 (34)
참고문헌 신청
Lee YH / 2014 / Nonlaboratory-based self-assessment screening score for non-alcoholic fatty liver disease : development, validation and comparison with other scores / PLoS One 9:e107584
Vernon G / 2011 / Systematic review : the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults / Aliment Pharmacol Ther 34:274~285
Jeong-Ju Yoo / 2019 / Recent research trends and updates on nonalcoholic fatty liver disease / Clinical and Molecular Hepatology 25(1):1~11
Angulo P / 2007 / The NAFLD fibrosis score : a noninvasive system that identifies liver fibrosis in patients with NAFLD / Hepatology 45:846~854
Angulo P / 2015 / Liver fibrosis, but no other histologic features, is associated with long-term outcomes of patients with nonalcoholic fatty liver disease / Gastroenterology 149:389~397
Vernon G / 2011 / Systematic review : the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults / Aliment Pharmacol Ther 34:274~285
Jeong-Ju Yoo / 2019 / Recent research trends and updates on nonalcoholic fatty liver disease / Clinical and Molecular Hepatology 25(1):1~11
Angulo P / 2007 / The NAFLD fibrosis score : a noninvasive system that identifies liver fibrosis in patients with NAFLD / Hepatology 45:846~854
Angulo P / 2015 / Liver fibrosis, but no other histologic features, is associated with long-term outcomes of patients with nonalcoholic fatty liver disease / Gastroenterology 149:389~397
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