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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 731 - 735 (5page)
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초록· 키워드
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Limbic-predominant age-related TDP-43 encephalopathy (LATE) is a recently established neurodegenerative disease entity. LATE neuropathological change (LATE-NC) is characterized by a TDP-43 proteinopathy that mainly involves the amygdala andmedial temporal structures, with or without hippocampal sclerosis. LATE-NC is typically observed in individuals aged 80 years orolder and manifests clinically as amnestic memory decline. Herein, we report a case of LATE diagnosed by brain autopsy in an82-year-old male who had an 11-year history of memory impairment. Pathological examination revealed high Alzheimer diseaseneuropathological changes, as well as amygdala-predominant Lewy body pathology. In addition, immunohistochemistry forTDP-43 revealed neuronal and glial cytoplasmic inclusions in the dentate gyrus of the hippocampus, amygdala, and inferior temporalcortex. Increasing awareness of the newly defined entity LATE will enhance our understanding of the neurodegenerativeprocesses that occur in the oldest individuals.
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등록된 정보가 없습니다.
참고문헌 (12)
참고문헌 신청
Neumann M / 2006 / Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis / Science 314:130~133
Bigio EH / 2011 / TDP-43 variants of frontotemporal lobar degeneration / J Mol Neurosci 45:390~401
Uchino A / 2015 / Incidence and extent of TDP-43 accumulation in aging human brain / Acta Neuropathol Commun 3:35
Amador-Ortiz C / 2007 / TDP-43 immunoreactivity in hippocampal sclerosis and Alzheimer’s disease / Ann Neurol 61:435~445
Nelson PT / 2019 / Limbic-predominant age-related TDP-43 encephalopathy(LATE) : consensus working group report / Brain 142:1503~1527
Bigio EH / 2011 / TDP-43 variants of frontotemporal lobar degeneration / J Mol Neurosci 45:390~401
Uchino A / 2015 / Incidence and extent of TDP-43 accumulation in aging human brain / Acta Neuropathol Commun 3:35
Amador-Ortiz C / 2007 / TDP-43 immunoreactivity in hippocampal sclerosis and Alzheimer’s disease / Ann Neurol 61:435~445
Nelson PT / 2019 / Limbic-predominant age-related TDP-43 encephalopathy(LATE) : consensus working group report / Brain 142:1503~1527
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