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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 365 - 374 (10page)
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초록· 키워드
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Purpose: The aim of this meta-analysis was to evaluate the efficacy and safety of imidafenacin for overactive bladder (OAB) induced by benign prostatic hyperplasia (BPH) in men receiving alpha-blocker monotherapy.Methods: We performed a systematic research of the PubMed, Embase, and Cochrane Library databases, and searched for studies about alpha-blocker with or without imidafenacin treatment for OAB in patients with BPH. We also investigated the original references of the included texts.Results: Four randomized controlled trials including 779 participants with BPH (389 in the alpha-blocker+imidafenacin group and 390 in the alpha-blocker only group) were studied. The main efficacy endpoint was the Overactive Bladder Symptom Score, which showed a mean difference of -1.88 (95% confidence interval, -2.32 to -1.44; P<0.00001), suggesting that alpha-blocker and imidafenacin treatment was effective in treating men with OAB. As other primary efficacy end points, the International Prostate Symptom Score (IPSS) total score (P=0.47), the IPSS storage symptom score (P=0.07), the IPSS voiding symptom score (P=0.60), and the IPSS quality of life score (P=0.18) indicated that 2 methods had no significant differences in treating men with OAB. In terms of safety, which was assessed using postvoid residual volume (P=0.05) and maximum flow rate (P=0.53), the analysis suggested that combination treatment was very well tolerated.Conclusions: This study suggested that imidafenacin plus alpha-blocker was an efficacious and safe treatment for OAB symptoms in BPH patients.
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참고문헌 (38)
참고문헌 신청
Bosch JL / 1995 / Natural history of benign prostatic hyperplasia : appropriate case definition and estimation of its prevalence in the community / Urology 46(3 Suppl A):34~40
Boyle P / 2003 / The prevalence of lower urinary tract symptoms in men and women in four centres. The UrEpik study / BJU Int 92:409~414
Witjes WP / 1997 / The International Continence Society"Benign Prostatic Hyperplasia"Study : international differences in lower urinary tract symptoms and related bother / J Urol 157:1295~1300
Athanasopoulos A / 2003 / Combination treatment with an alpha-blocker plus an anticholinergic for bladder outlet obstruction: a prospective, randomized, controlled study / J Urol 169:2253~2256
Lee KS / 2005 / Combination treatment with propiverine hydrochloride plus doxazosin controlled release gastrointestinal therapeutic system formulation for overactive bladder and coexisting benign prostatic obstruction:a prospective, randomized, controlled multicenter study / J Urol 174(4 Pt 1):1334~1338
Boyle P / 2003 / The prevalence of lower urinary tract symptoms in men and women in four centres. The UrEpik study / BJU Int 92:409~414
Witjes WP / 1997 / The International Continence Society"Benign Prostatic Hyperplasia"Study : international differences in lower urinary tract symptoms and related bother / J Urol 157:1295~1300
Athanasopoulos A / 2003 / Combination treatment with an alpha-blocker plus an anticholinergic for bladder outlet obstruction: a prospective, randomized, controlled study / J Urol 169:2253~2256
Lee KS / 2005 / Combination treatment with propiverine hydrochloride plus doxazosin controlled release gastrointestinal therapeutic system formulation for overactive bladder and coexisting benign prostatic obstruction:a prospective, randomized, controlled multicenter study / J Urol 174(4 Pt 1):1334~1338
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