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논문 기본 정보

자료유형
학술저널
저자정보
Yi-Wen Ting (Faculty of Medicine University of Malaya) Amanda Shen-Yee Kong (Faculty of Medicine University of Malaya) Shamsul Mohd Zain (Department of Pharmacology Faculty of Medicine University of Malaya) Wah-Kheong Chan (Department of Medicine Faculty of Medicine University of Malaya) Hwa-Li Tan (Department of Pharmacology Faculty of Medicine University of Malaya) Zahurin Mohamed (Department of Pharmacology Faculty of Medicine University of Malaya) Yuh-Fen Pung (Department of Biomedical Sciences University of Nottingham (Malaysia Campus)) Rosmawati Mohamed (Department of Medicine Faculty of Medicine University of Malaya)
저널정보
대한간학회 Clinical and Molecular Hepatology Clinical and Molecular Hepatology 제27권 제3호
발행연도
2021.1
수록면
486 - 498 (13page)

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HSBackground/ Aims: 17β-hydroxysteroid dehydrogenase 13 (HSD17B13) variants were recently reported to have significantly lower odds of non-alcoholic fatty liver disease (NAFLD). This is a two-part study that aimed to evaluate the association of HSD17B13 variants with NAFLD and its histological severity, and to identify the association of the variants with clinical outcomes in a cohort of biopsy-proven NAFLD patients. Methods: Consecutive biopsy-proven NAFLD patients and controls without fatty liver were recruited for this study between 2009 and 2014. Genotyping for HSD17B13 variants was performed using rhAmp assays. A total of 165 patients with NAFLD were monitored up until August 2019. Clinical outcomes were recorded. Results: HSD17B13 rs72613567 TA allele and rs6834314 G allele were associated with lower odds of non-alcoholic steatohepatitis (NASH) in the overall cohort and among ethnic Chinese, but not among ethnic Malays or Indians (P<0.05). During a mean follow-up of 89 months, 32 patients (19.4%) experienced at least one clinical outcome (cardiovascular events, n=22; liver-related complications, n=6; extra-hepatic malignancy, n=5; and mortality, n=6). The rs72613567 homozygous TA allele and the rs6834314 homozygous G allele were independently associated with a lower incidence of liver-related complications (hazard ratio [HR], 0.004; 95% confidence interval [CI], 0.00?0.64; P=0.033 and HR, 0.01; 95% CI, 0.00?0.97; P=0.048, respectively) and were associated with lower grade of hepatocyte ballooning among the ethnic Chinese. Conclusion: HSD17B13 rs72613567 and rs6834314 variants were inversely associated with NAFLD and NASH, and were associated with lower incidence of adverse liver outcomes in a cohort of multi-ethnic Asian patients with NAFLD.
#Polymorphism #Genetic #Genetic variation #Liver diseases #Asia #Malaysia

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참고문헌 (31)

참고문헌 신청
Chalasani N / 2018 / The diagnosis and management of nonalcoholic fatty liver disease : practice guidance from the American association for the study of liver diseases / Hepatology 67:328~357 google schola Younossi Z / 2019 / Nonalcoholic steatohepatitis is the fastest growing cause of hepatocellular carcinoma in liver transplant candidates / Clin Gastroenterol Hepatol 17:748~755.e3 google schola Sookoian S / 2017 / Genetic predisposition in nonalcoholic fatty liver disease / Clin Mol Hepatol 23:1~12 google schola Romeo S / 2008 / Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease / Nat Genet 40:1461~1465 google schola Liu YL / 2014 / Carriage of the PNPLA3 rs738409 C >G polymorphism confers an increased risk of non-alcoholic fatty liver disease associated hepatocellular carcinoma / J Hepatol 61:75~81 google schola

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