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논문 기본 정보

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학술저널
저자정보
Se Ri Ryu (Department of Internal Medicine Soonchunhyang University Seoul Hospital) Jeong-Ju Yoo (Department of Internal Medicine Soonchunhyang University Bucheon Hospital) Seong Hee Kang (Department of Internal Medicine Yonsei University Wonju College of Medicine) Soung Won Jeong (Department of Internal Medicine Soonchunhyang University Seoul Hospital) Moon Young Kim (Department of Internal Medicine Yonsei University Wonju College of Medicine) Young Kyu Cho (Department of Internal Medicine Soonchunhyang University Seoul Hospital) Young Chang (Department of Internal Medicine Soonchunhyang University Seoul Hospital) Sang Gyune Kim (Department of Internal Medicine Soonchunhyang University Bucheon Hospital) Jae Young Jang (Department of Internal Medicine Soonchunhyang University Seoul Hospital) Young Seok Kim (Department of Internal Medicine Soonchunhyang University Bucheon Hospital) Soon Koo Baik (Department of Internal Medicine Wonju Severance Christian Hospital) Yong Jae Kim (Department of Radiology Soonchunhyang University Seoul Hospital) Su Yeon Park (Department of Biostatistics Soonchunhyang University Seoul Hospital) Baigal Baymbajav (UB Songdo Hospital)
저널정보
대한간학회 Clinical and Molecular Hepatology Clinical and Molecular Hepatology 제27권 제1호
발행연도
2021.1
수록면
197 - 206 (10page)

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Background/Aims: The hepatic venous pressure gradient (HVPG) reflects portal hypertension, but its measurement is invasive. Transient elastography (TE) is a noninvasive method for evaluating liver stiffness (LS). We investigated the correlation between the value of LS, LS to platelet ratio (LPR), LS-spleen diameter-to-platelet ratio score (LSPS) and HVPG according to the etiology of cirrhosis, especially focused on alcoholic cirrhosis. Methods: Between January 2008 and March 2017, 556 patients who underwent HVPG and TE were consecutively enrolled. We evaluated LS, LPR, and LSPS according to the etiology of cirrhosis and analyzed their correlations with HVPG. Results: The LS value was higher in patients with alcoholic cirrhosis than viral cirrhosis based on the HVPG (43.5 vs. 32.0 kPa, P<0.001). There were no significant differences in the LPR or LSPS between alcoholic and viral cirrhosis groups, and the areas under the curves for the LPR and LSPS in subgroups according to HVPG levels were not superior to that for LS. In alcoholic cirrhosis, the LS cutoff value for predicting an HVPG ≥10 mmHg was 32.2 kPa with positive predictive value (PPV) of 94.5% and 36.6 kPa for HVPG ≥12 mmHg with PPV of 91.0%. Conclusions: The LS cutoff value should be determined separately for patients with alcoholic and viral cirrhosis. In alcoholic cirrhosis, the LS cutoff values were 32.2 and 36.6 kPa for predicting an HVPG ≥10 and ≥12 mmHg, respectively. However, there were no significant differences in the LPR or LSPS between alcoholic and viral cirrhosis groups.
#Liver cirrhosis #Hypertension #Portal #Elastography

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참고문헌 (34)

참고문헌 신청
Burroughs AK / 2002 / Assessment of therapeutic benefit of antiviral therapy in chronic hepatitis C: is hepatic venous pressure gradient a better end point? / Gut 50:425~427 google schola Burroughs AK / 1992 / Natural history and prognosis of variceal bleeding / Baillieres Clin Gastroenterol 6:437~450 google schola D’Amico G / 2006 / Natural history and prognostic indicators of survival in cirrhosis: a systematic review of 118 studies / J Hepatol 44:217~231 google schola Ripoll C / 2009 / Hepatic venous pressure gradient predicts development of hepatocellular carcinoma independently of severity of cirrhosis / J Hepatol 50:923~928 google schola Said A / 2004 / Model for end stage liver disease score predicts mortality across a broad spectrum of liver disease / J Hepatol 40:897~903 google schola

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