메뉴 건너뛰기
.. 내서재 .. 알림
소속 기관/학교 인증
인증하면 논문, 학술자료 등을  무료로 열람할 수 있어요.
한국대학교, 누리자동차, 시립도서관 등 나의 기관을 확인해보세요
(국내 대학 90% 이상 구독 중)
로그인 회원가입 고객센터 ENG
주제분류
인문학
인문학 일반 역사학 철학 종교학 어문학 기타 인문학
사회과학
사회과학 일반 경영학 관광학 교육학 군사학 문헌정보학 법학 사회학 신문방송학 심리과학 정치외교학 지리학 행정학 경제학 무역학 인류학 기타 사회과학
자연과학
자연과학 일반 물리학 생물학 생활과학 수학·통계학 천문학 지구과학 화학 기타 자연과학
공학
공학 일반 건축공학 기계공학 산업공학 재료·에너지공학 전기전자공학 조선해양공학 화학공학 컴퓨터학 기타공학
의약학
의학 일반 간호학 수의학 약학 한의학 기초의학 임상의학 기타 의약학
농수해양학
농수해양학 일반 농학 수산학 식품과학 임학 축산학 해상운송학 기타 농수해양학
예술체육학
예술 일반 디자인 미술 미용 사진 음악학 의상 체육 공연매체예술 기타 예술체육학
복합학
학제간연구 과학기술학 뇌인지과학 기술정책 기타 복합학

ENG

추천
검색

논문 기본 정보

자료유형
학술저널
저자정보
Lim Dae Hyun (Departments of Internal Medicine Hanyang University College of Medicine Seoul Korea) Kim Mimi (Departments of Radiology Hanyang University College of Medicine Seoul Korea) Jun Dae Won (Departments of Internal Medicine Hanyang University College of Medicine Seoul Korea) Kwak Min Jung (Department of Data Information and Statistics Pyeongtaek University Pyeongtaek Korea) Yoon Jai Hoon (Departments of Internal Medicine Hanyang University College of Medicine Seoul Korea) Lee Kang Nyeong (Departments of Internal Medicine Hanyang University College of Medicine Seoul Korea) Lee Hang Lak (Departments of Internal Medicine Hanyang University College of Medicine Seoul Korea) Lee Oh Young (Departments of Internal Medicine Hanyang University College of Medicine Seoul Korea) Yoon Byung Chul (Departments of Internal Medicine Hanyang University College of Medicine Seoul Korea) Choi Ho Soon (Departments of Internal Medicine Hanyang University College of Medicine Seoul Korea) Kang Bo Kyeong (Departments of Radiology Hanyang University College of Medicine Seoul Korea)
저널정보
거트앤리버 발행위원회 Gut and Liver Gut and Liver 제15권 제1호
발행연도
2021.1
수록면
109 - 116 (8page)

이용수

표지
📌
연구주제
📖
연구배경
🔬
연구방법
🏆
연구결과
AI에게 요청하기
추천
검색

초록· 키워드

오류제보하기
Background/Aims: To date, studies on various noninvasive techniques have been suggested to evaluate the degree of liver fibrosis. We aimed to investigate the diagnostic performance of serum asialo α1-acid glycoprotein (AsAGP) in the diagnosis of liver cirrhosis compared with chronic hepatitis for clinically useful result. Methods: We conducted a case-control study of 96 patients with chronic liver disease. Chronic hepatitis was defined as the presence of chronic liver disease on ultrasonography, with a liver stiffness of less than 5.0 kPa as shown on magnetic resonance elastography (MRE). Liver cirrhosis was defined as liver stiffness of more than 5.0 kPa on MRE. The serum AsAGP concentration was compared between the two groups. Results: Serum AsAGP levels were significantly higher in patients with cirrhosis than in those with chronic hepatitis (1.83 μg/mL vs 1.42 μg/mL, p<0.001). Additionally, when comparing patients in each cirrhotic group (Child-Pugh grades A, B, and C) to those with chronic hepatitis, AsAGP levels were significantly higher in all the cirrhotic groups (p<0.05, p<0.01, p<0.001, respectively). The sensitivity and specificity of AsAGP for detecting cirrhosis were 79.2% and 64.6%, respectively, and the area under the curve value was 0.733. The best diagnostic cutoff to predict cirrhosis was 1.4 μg/mL. AsAGP and bilirubin were found to be independent risk factors for the prediction of cirrhosis in the logistic regression analysis. Conclusions: Serum AsAGP showed an acceptable diagnostic performance in predicting liver cirrhosis.
#Asialo alpha 1-acid glycoprotein #Liver cirrhosis #Chronic hepatitis #Magnetic resonance elastography

목차

등록된 정보가 없습니다.

참고문헌 (14)

참고문헌 신청
Poynard T / 2003 / A comparison of fibrosis progression in chronic liver diseases / J Hepatol 38:257~265 google schola Friedman SL / 2008 / Mechanisms of hepatic fibrogenesis / Gastroenterology 134:1655~1669 google schola Lambrecht J / 2018 / Prospects in non-invasive assessment of liver fibrosis: liquid biopsy as the future gold standard? / Biochim Biophys Acta Mol Basis Dis 1864(4 Pt A):1024~1036 google schola Wong MW / 1979 / Evidence for reduced uptake of asialo-alpha 1-acid glycoprotein during the acute phase response to inflammation / Life Sci 25:827~833 google schola Hochepied T / 2003 / Alpha(1)-acid glycoprotein : an acute phase protein with inflammatory and immunomodulating properties / Cytokine Growth Factor Rev 14:25~34 google schola

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!

이 논문의 저자 정보

최근 본 자료

전체보기

댓글(0)

0