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연세대학교 의과대학 Yonsei Medical Journal Yonsei Medical Journal 제60권 제5호
발행연도
2019.1
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440 - 445 (6page)

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Purpose: Patients with liver cirrhosis are considered to be at risk for additional adverse events during endoscopic retrogradecholangiopancreatography (ERCP). The present study was designed as a propensity-score matched analysis to investigate whethercirrhotic liver increases the risk of bleeding complications in patients undergoing ERCP. Materials and Methods: In total, 8554 patients who underwent ERCP from January 2005 to December 2015 were retrospectivelyanalyzed. To adjust for the imbalance between patients with and those without liver cirrhosis, 1:3 propensity score matching wasperformed according to age and sex. Results: Liver cirrhosis was identified in 264 (3.1%) patients. After propensity score matching, a total of 768 patients were includedin each of the cirrhotic (n=192) and non-cirrhotic groups (n=576). Post-procedure bleeding (10.9% vs. 4.7%, p=0.003) was morefrequently observed in patients with liver cirrhosis than in those without. In multivariate analyses, liver cirrhosis was identified asan independent risk factor associated with post-ERCP bleeding (p=0.003) after further adjustment for prothrombin time, antiplatelet/coagulant, duration of ERCP, and stent insertion. Child-Pugh (CP) class C was found to be associated with an increased incidenceof post-ERCP bleeding in patients with cirrhosis (odds ratio 6.144, 95% confidence interval 1.320–28.606; p=0.021). Conclusion: The incidence of post-ERCP bleeding in patients with liver cirrhosis was higher than that in patients without livercirrhosis. In particular, CP class C cirrhosis was significantly associated with post-ERCP bleeding.

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