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Fenbendazole (FBZ) is one of the safest anthelmintic drugs. FBZ has been found to have anti-cancer effects by destabilizing microtubules. In this study, a synergistic effect of paclitaxel (PA), a microtubule-stabilizing anti-cancer agent, and FBZ was investigated on HL-60 cells, a human leukemia cell line. The metabolic activity of cells significantly decreased and the nucleus morphology upon the treatment of FBZ and PA based on 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide assay and Hoechst 33342 staining, respectively. To investigate the involvement of reactive oxygen species (ROS), the metabolic activity of the cells after treatment of N-acetyl-L-cysteine (NAC) was measured. Indeed, NAC significantly increased the metabolic activity of the cells treated with FBZ and PA, suggesting that both drugs affect at least in part via ROS. Furthermore, FBZ and PA increased cell death in an annexin V- fluorescein isothiocyanate/propidium iodide staining assay. Taken together, FBZ and PA have a synergistic anti-cancer activity on HL-60 cells at a certain concentration. These results may provide researchers and clinicians in cancer-related fields with some valuable information to broaden the use of FBZ.
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등록된 정보가 없습니다.
참고문헌 (19)
참고문헌 신청
Chio IIC / 2017 / ROS in Cancer : The Burning Question / Trends Mol Med 23:411~429
Dogra N / 2018 / Fenbendazole acts as a moderate microtubule destabilizing agent and causes cancer cell death by modulating multiple cellular pathways / Sci Rep 8:11926
Dröge W / 2002 / Free radicals in the physiological control of cell function / Physiol Rev 82:47~95
Duan Q / 2013 / Fenbendazole as a potential anticancer drug / Anticancer Res 33:355~362
Yong Han / 2020 / Fenbendazole의 항암활성에서 활성산소종의 관련성 / 대한수의학회지 60(2):79~83
Dogra N / 2018 / Fenbendazole acts as a moderate microtubule destabilizing agent and causes cancer cell death by modulating multiple cellular pathways / Sci Rep 8:11926
Dröge W / 2002 / Free radicals in the physiological control of cell function / Physiol Rev 82:47~95
Duan Q / 2013 / Fenbendazole as a potential anticancer drug / Anticancer Res 33:355~362
Yong Han / 2020 / Fenbendazole의 항암활성에서 활성산소종의 관련성 / 대한수의학회지 60(2):79~83
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