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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 351 - 374 (24page)
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Objectives: This study investigates the mechanism of Hwanggeum-tang (HGT) and Gamchosasim-tang (GST) on inflammatory bowel disease (IBD). Methods: The mice (C57BL/6N) were treated with distilled water and 3% dextran sulfate sodium (DSS) to experimentally induce ulcerative colitis. The mice were divided into 7 groups of (6 mice: normal, negative control, positive control (with sulfasalazine), 4 experimental groups (with HGT and GST, respectively). RAW 264.7 cells were used for cell experiments. The experiment was conducted in two ways: in vitro and in vivo. Results: In the experimental group (HGT, GST) of in vitro experiments, NO production decreased, and significant changes in gene expression and protein activation were observed. The length of the colon recovered in the experimental groups (HGT, GST) of the in vivo experiment was longer than that of the negative control group, and the mucosal barrier was recovered. Sone significant changes in the amount of mRNA expression were partially observed, and significant changes in protein activation also were confirmed. Conclusions: HGT and GST are effective in treating IBD caused by DSS. In the same herbal preparation group, the higher the concentration, the better the experimental effect, and when the same concentration was tested, HGT was more effective than GST. Herbal medicine has a higher antioxidant effect than sulfasalazine, so it is also excellent for cell protection.
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참고문헌 (48)
참고문헌 신청
Choi EJ / 2019 / Enterococcus faecalis EF-2001 protects DNBS-induced inflammatory bowel disease in mice model / PloS one 14(2):e0210854
Korean Assosiation for the Study of Intestinal Diseases / 2003 / Easy to understand ulcerative colitis / Koonja :8
Su C / 2007 / A meta-analysis of the placebo rates of remission and response in clinical trials of active ulcerative colitis / Gastroenterology 132(2):516~526
진윤태 / 2009 / 궤양성 대장염의 최신치료 / 대한내과학회지 76(6):654~660
Lin Z / 2019 / Application of Herbaceous Medications for Inflammatory Bowel Disease as a Complementary and Alternative Therapy / Inflammatory bowel diseases 25(12):1886~1895
Korean Assosiation for the Study of Intestinal Diseases / 2003 / Easy to understand ulcerative colitis / Koonja :8
Su C / 2007 / A meta-analysis of the placebo rates of remission and response in clinical trials of active ulcerative colitis / Gastroenterology 132(2):516~526
진윤태 / 2009 / 궤양성 대장염의 최신치료 / 대한내과학회지 76(6):654~660
Lin Z / 2019 / Application of Herbaceous Medications for Inflammatory Bowel Disease as a Complementary and Alternative Therapy / Inflammatory bowel diseases 25(12):1886~1895
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