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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 655 - 666 (12page)
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Background/Aims: In inflammatory bowel disease (IBD), repeated bouts of remission and relapse occur in patients and can impose a risk of colitis-associated cancer. We hypothesized that plant extracts of Atractylodes macrocephala (AM) or Taraxacum herba (TH) may be better than sulfasalazine for treating this disease because these extracts can promote additional regeneration. Methods: Murine intestinal epithelial IEC-6 cells were pretreated with AM or TH before a lipopolysaccharide (LPS)-induced challenge. Acute colitis was induced with 7 days of dextran sulfate sodium (DSS) in male C57BL/6 mice, and extracts of AM and TH were administered for 2 weeks before DSS administration. Results: In vitro studies demonstrated that AM or TH treatment reduced LPS-induced COX-2 and tumor necrosis factor-α mRNA levels but increased heme oxygenase-1 (HO-1). Oral preadministration of AM and TH rescued mice from DSS-induced colitis by inhibiting inflammatory mediators via inactivated extracellular signal regulated kinase and repressed nuclear factor κB and signal transducer and activator of transcription 3, but the effect was weaker for sulfasalazine than that for the extracts. Anti-inflammatory activities occurred via the inhibition of macrophage and T lymphocyte infiltrations. Unlike sulfasalazine, which did not induce HO-1, TH extracts afforded significant HO-1 induction. Conclusions: Because the AM or TH extracts were far superior in preventing DSS-induced colitis than sulfasalazine, AM or TH extracts can be considered natural agents that can prevent IBD relapse.
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참고문헌 (25)
참고문헌 신청
Ahmad VU / 2000 / Taraxacin, a new guaianolide from Taraxacum wallichii / J Nat Prod 63 : 1010 ~ 1011
Cheon JH / 2006 / Plant sterol guggulsterone inhibits nuclear factor-kappaB signaling in intestinal epithelial cells by blocking IkappaB kinase and ameliorates acute murine
Cooper HS / 1993 / Clinicopathologic study of dextran sulfate sodium experimental murine colitis / Lab Invest 69 : 238 ~ 249
Cross RK / 2003 / Nitric oxide in inflammatory bowel disease / Inflamm Bowel Dis 9 : 179 ~ 189
Dong H / 2008 / Anti-inflammatory components isolated from Atractylodes macrocephala Koidz / Nat Prod Res 22 : 1418 ~ 1427
Cheon JH / 2006 / Plant sterol guggulsterone inhibits nuclear factor-kappaB signaling in intestinal epithelial cells by blocking IkappaB kinase and ameliorates acute murine
Cooper HS / 1993 / Clinicopathologic study of dextran sulfate sodium experimental murine colitis / Lab Invest 69 : 238 ~ 249
Cross RK / 2003 / Nitric oxide in inflammatory bowel disease / Inflamm Bowel Dis 9 : 179 ~ 189
Dong H / 2008 / Anti-inflammatory components isolated from Atractylodes macrocephala Koidz / Nat Prod Res 22 : 1418 ~ 1427
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