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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 343 - 352 (10page)
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Objective To investigate the glial cell and AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptor activity after surgery for disc herniation pain model. Methods In total, 83 Sprague-Dawley rats were randomly assigned to the following groups: control (n=16), sham-operated (n=4), rats for pain behavior evaluation (n=3), nucleus pulposus-exposed groups for AMPA receptors (n=30), and glial cell (n=30). The rats were tested for mechanical allodynia; immunohistochemical staining for AMPA receptors (GluA1 and GluA2) and glial cells (OX-42 and glial fibrillary acid protein [GFAP]) in the spinal dorsal horn was performed on postoperative days 3, 7, and 14. Results Mechanical withdrawal thresholds decreased after surgery, and this effect was maintained for up to 14 days. Immunohistochemical expression of GluA1 and GluA2 in the spinal dorsal horn had increased quantitatively on postoperative days 3 and 7 (p<0.05) to levels similar to that of the controls on postoperative day 14. Moreover, immunohistochemical expression of OX-42 and GFAP showed similar changes to AMPA receptors after surgery. Although the activity of AMPA receptors and glial cells achieved normalcy, the mechanical withdrawal threshold of the hind paw remained decreased 38 days after surgery. Conclusion The rat model of lumbar disc herniation showed increased expression of AMPA receptor and glial cell activity in the spinal dorsal horn 3 and 7 days after surgery, which deceased to control levels at 14 days. The AMPA receptors and glial cell activations showed similar patterns after disc herniation surgery.
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참고문헌 (32)
참고문헌 신청
Garry EM / 2004 / A new view on how AMPA receptors and their interacting proteins mediate neuropathic pain / Pain 109:210~213
Kopach O / 2013 / Extrasynaptic AMPA receptors in the dorsal horn : evidence and functional significance / Brain Res Bull 93:47~56
Park JS / 2009 / Persistent inflammation induces GluR2 internalization via NMDA receptor-triggered PKC activation in dorsal horn neurons / J Neurosci 29:3206~3219
Kopach O / 2011 / Inflammation alters trafficking of extrasynaptic AMPA receptors in tonically firing lamina II neurons of the rat spinal dorsal horn / Pain 152:912~923
Tsuda M / 2016 / Microglia in the spinal cord and neuropathic pain / J Diabetes Investig 7:17~26
Kopach O / 2013 / Extrasynaptic AMPA receptors in the dorsal horn : evidence and functional significance / Brain Res Bull 93:47~56
Park JS / 2009 / Persistent inflammation induces GluR2 internalization via NMDA receptor-triggered PKC activation in dorsal horn neurons / J Neurosci 29:3206~3219
Kopach O / 2011 / Inflammation alters trafficking of extrasynaptic AMPA receptors in tonically firing lamina II neurons of the rat spinal dorsal horn / Pain 152:912~923
Tsuda M / 2016 / Microglia in the spinal cord and neuropathic pain / J Diabetes Investig 7:17~26
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