지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 10 - 15 (6page)
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초록· 키워드
오류제보하기
Background: To identify a new strategy for postoperative pain management, we investigated the analgesic effects of allopregnanolone (Allo) in an incisional pain model, and also assessed its effects on the activities of the primary afferent fibers at the dorsal horn.Methods: In experiment 1, 45 rats were assigned to Control, Allo small-dose (0.16 mg/kg), and Allo large-dose (1.6 mg/kg) groups (n = 15 in each). The weight bearing and mechanical withdrawal thresholds of the hind limb were measured before and at 2, 24, 48, and 168 h after Brennan’s surgery. In experiment 2, 16 rats were assigned to Control and Allo (0.16 mg/kg) groups (n = 8 in each). The degree of spontaneous pain was measured using the grimace scale after the surgery. Activities of the primary afferent fibers in the spinal cord (L6) were evaluated using immunohistochemical staining.Results: In experiment 1, the withdrawal threshold of the Allo small-dose group was significantly higher than that of the Control group at 2 h after surgery. Intergroup differences in weight bearing were not significant. In experiment 2, intergroup differences in the grimace scale scores were not significant. Substance P release in the Allo (0.16 mg/kg) group was significantly lower than that in the Control group.Conclusions: Systemic administration of Allo inhibited mechanical allodynia and activities of the primary afferent fibers at the dorsal horn in a rat postoperative pain model. Allo was proposed as a candidate for postoperative pain management. (Korean J Pain 2018; 31: 10-5)
목차
등록된 정보가 없습니다.
참고문헌 (17)
참고문헌 신청
Tan M / 2015 / Optimizing pain management to facilitate enhanced recovery after surgery pathways / Can J Anaesth 62:203~218
Apfelbaum JL / 2003 / Postoperative pain experience: results from a national survey suggest postoperative pain continues to be undermanaged / Anesth Analg 97:534~540
김신형 / 2013 / Patient-controlled Epidural Analgesia with Ropivacaine and Fentanyl: Experience with 2,276 Surgical Patients / The Korean Journal of Pain 26(1):39~45
Frye CA / 1994 / Progesterone metabolites, effective at the GABAA receptor complex, attenuate pain sensitivity in rats / Brain Res 643:194~203
Pathirathna S / 2005 / 5alpha-reduced neuroactive steroids alleviate thermal and mechanical hyperalgesia in rats with neuropathic pain / Pain 117:326~339
Apfelbaum JL / 2003 / Postoperative pain experience: results from a national survey suggest postoperative pain continues to be undermanaged / Anesth Analg 97:534~540
김신형 / 2013 / Patient-controlled Epidural Analgesia with Ropivacaine and Fentanyl: Experience with 2,276 Surgical Patients / The Korean Journal of Pain 26(1):39~45
Frye CA / 1994 / Progesterone metabolites, effective at the GABAA receptor complex, attenuate pain sensitivity in rats / Brain Res 643:194~203
Pathirathna S / 2005 / 5alpha-reduced neuroactive steroids alleviate thermal and mechanical hyperalgesia in rats with neuropathic pain / Pain 117:326~339
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