지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Vibration is a mechanical cue that can be applied to adipose tissues for the purpose of treating obesity. However, the exact correlation between vibration and other anti-adipogenic pathways, such as development of cytoskeleton and apoptosis, remains unknown. The objective of this study was to investigate the unknown anti-adipogenic effects of vibration with varied frequencies on preadipocytes. 3T3-L1 preadipocytes were cultured in Dulbecco’s modified Eagle’s medium (DMEM) containing 5% calf serum at 37 oC with 5% CO2 in a humidified incubator. Vibration was generated using Arduino Uno microcontroller and vibration motor module with 1 V DC, and applied to preadipocytes for 3 days. Frequency conditions were set to 20, 55, and 90 Hz. Then, the expressions of p38 pathway, ROCK-1, α-actinin, Bax, Bcl-2, caspase-9, 8, and 3 were analyzed with western blot. As a result, p38 pathway was inhibited in 55 and 90 Hz while ROCK-1 and α-actinin were expressed in 20 Hz. Caspase-3, a terminal apoptotic factor, was activated in 20 Hz via extrinsic pathway rather than intrinsic pathway. Results suggest that various frequencies of vibration can inhibit adipogenesis via different pathways which sheds light on future mechanotransduction applications of vibration for the treatment of obesity.
목차
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참고문헌 (25)
참고문헌 신청
Martino F / 2018 / Cellular mechanotransduction : from tension to function / Front Physiol 9:824
Wang N / 2009 / Mechanotransduction at a distance : mechanically coupling the extracellular matrix with the nucleus / Nat Rev Mol Cell Biol 10(1):75~82
Shoham N / 2012 / Mechanotransduction in adipocytes / J Biomech 45(1):1~8
Hossain MG / 2010 / Compressive force inhibits adipogenesis through COX-2-mediated down-regulation of PPARgamma2 and C/EBPalpha / J Biosci Bioeng 109(3):297~303
Yuan Y / 2015 / Mechanobiology and mechanotherapy of adipose tissue-effect of mechanical force on fat tissue engineering / Plast Reconstr Surg Glob Open 3(12)
Wang N / 2009 / Mechanotransduction at a distance : mechanically coupling the extracellular matrix with the nucleus / Nat Rev Mol Cell Biol 10(1):75~82
Shoham N / 2012 / Mechanotransduction in adipocytes / J Biomech 45(1):1~8
Hossain MG / 2010 / Compressive force inhibits adipogenesis through COX-2-mediated down-regulation of PPARgamma2 and C/EBPalpha / J Biosci Bioeng 109(3):297~303
Yuan Y / 2015 / Mechanobiology and mechanotherapy of adipose tissue-effect of mechanical force on fat tissue engineering / Plast Reconstr Surg Glob Open 3(12)
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