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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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초록· 키워드
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Superparamagnetic iron oxide nanoparticles (SPIONs) are approved by the Food and Drug Administration (FDA) in the United States. SPIONs are used in magnetic resonance imaging (MRI) as contrast agents and targeted delivery in nanomedicine using external magnet sources. SPIONs act as an artificial peroxidase (i.e., nanozyme), and these reactions were highly stable in various pH conditions and temperatures. In this study, we report a nanozyme ability of the clustered SPIONs (CSPIONs) synthesized by the oil-in-water (O/W) method and coated with biocompatible poly(lactic-co-glycolic acid) (PLGA). We hypothesize that the CSPIONs can have high sensitivity toward H2O2 derived from the reaction between a fixed amount of glucose and glucose oxidase (GOX). As a result, CSPIONs oxidized a 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) diammonium salt (ABTS) commonly used as a substrate for hydrogen peroxidase in the presence of H2O2, leading to a change in the color of the substrate. We also utilized a colorimetric assay at 417 nm using various glucose concentrations from 5 mM to 1.25 μM to validate β-D-glucose detection. This study demonstrated that the absorbance value increases along with increasing the glucose level. The results were highly repeated at concentrations below 5 mM (all standard deviations < 0.03). Moreover, the sensitivity and limit of detection were 1.50 and 5.44 μM, respectively, in which CSPIONs are more responsive to glucose than SPIONs. In conclusion, this study suggests that CSPIONs have the potential to be used for glucose detection in diabetic patients using a physiological fluid such as ocular, saliva, and urine.
목차
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참고문헌 (32)
참고문헌 신청
Kandasamy Ganeshlenin / 2015 / Recent advances in superparamagnetic iron oxide nanoparticles(SPIONs)for in vitro and in vivo cancer nanotheranostics / International journal of pharmaceutics 496(2):191~218
Dulińska-Litewka, Joanna / 2019 / Superparamagnetic iron oxide nanoparticles-Current and prospective medical applications / Materials 12(4):617
Bae Ki Hyun / 2012 / Chitosan oligosaccharide-stabilized ferrimagnetic iron oxide nanocubes for magnetically modulated cancer hyperthermia / ACS nano 6(6):5266~5273
Kolen’ko, Yury V / 2014 / Large-scale synthesis of colloidal Fe3O4nanoparticles exhibiting high heating efficiency in magnetic hyperthermia / The Journal of Physical Chemistry C 118(16):8691~8701
Nam Nguyen Hoai / 2016 / Folate attached, curcumin loaded Fe3O4 nanoparticles: A novel multifunctional drug delivery system for cancer treatment / Materials Chemistry and Physics 172:98~104
Dulińska-Litewka, Joanna / 2019 / Superparamagnetic iron oxide nanoparticles-Current and prospective medical applications / Materials 12(4):617
Bae Ki Hyun / 2012 / Chitosan oligosaccharide-stabilized ferrimagnetic iron oxide nanocubes for magnetically modulated cancer hyperthermia / ACS nano 6(6):5266~5273
Kolen’ko, Yury V / 2014 / Large-scale synthesis of colloidal Fe3O4nanoparticles exhibiting high heating efficiency in magnetic hyperthermia / The Journal of Physical Chemistry C 118(16):8691~8701
Nam Nguyen Hoai / 2016 / Folate attached, curcumin loaded Fe3O4 nanoparticles: A novel multifunctional drug delivery system for cancer treatment / Materials Chemistry and Physics 172:98~104
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