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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제24권 제6호
- 발행연도
- 2020.1
- 수록면
- 481 - 492 (12page)
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The present study aimed to examine the effect of allyl isothiocyanate (AITC) on chronic obstructive pulmonary disease and to investigate whether upregulation of multidrug resistance-associated protein 1 (MRP1) associated with the activation of the PARK7 (DJ-1)/nuclear factor erythroid 2-related factor 2 (Nrf2) axis. Lung function indexes and histopathological changes in mice were assessed by lung function detection and H&E staining. The expression levels of Nrf2, MRP1, heme oxygenase-1 (HO-1), and DJ-1 were determined by immunohistochemistry, Western blotting and reverse transcription-quantitative polymerase chain reaction. Next, the expression of DJ-1 in human bronchial epithelial (16HBE) cells was silenced by siRNA, and the effect of DJ-1 expression level on cigarette smoke extract (CSE)-stimulated protein degradation and AITC-induced protein expression was examined. The expression of DJ-1, Nrf2, HO-1, and MRP1 was significantly decreased in the wild type model group, while the expression of each protein was significantly increased after administration of AITC. Silencing the expression of DJ-1 in 16HBE cells accelerated CSE-induced protein degradation, and significantly attenuated the AITC-induced mRNA and protein expression of Nrf2 and MRP1. The present study describes a novel mechanism by which AITC induces MRP1 expression by protecting against CS/CSEmediated DJ-1 protein degradation via activation of the DJ-1/Nrf2 axis.
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참고문헌 (35)
참고문헌 신청
Yang SR / 2006 / Cigarette smoke induces proinflammatory cytokine release by activation of NF-kappaB and posttranslational modifications of histone deacetylase in macrophages / Am J Physiol Lung Cell Mol Physiol 291:L46~L57
Lapperre TS / 2006 / Relation between duration of smoking cessation and bronchial inflammation in COPD / Thorax 61:115~121
Cole SP / 2014 / Targeting multidrug resistance protein 1(MRP1, ABCC1) : past, present, and future / Annu Rev Pharmacol Toxicol 54:95~117
van der Deen M / 2006 / Diminished expression of multidrug resistance-associated protein 1(MRP1)in bronchial epithelium of COPD patients / Virchows Arch 449:682~688
Wang DL / 2012 / Effects of huatan jiangqi capsule on the levels of multi-drug resistance-associated protein 1 in the bronchial epithelial cells of model rats with chronic obstructive pulmonary disease / Zhongguo Zhong Xi Yi Jie He Za Zhi 32:955~959
Lapperre TS / 2006 / Relation between duration of smoking cessation and bronchial inflammation in COPD / Thorax 61:115~121
Cole SP / 2014 / Targeting multidrug resistance protein 1(MRP1, ABCC1) : past, present, and future / Annu Rev Pharmacol Toxicol 54:95~117
van der Deen M / 2006 / Diminished expression of multidrug resistance-associated protein 1(MRP1)in bronchial epithelium of COPD patients / Virchows Arch 449:682~688
Wang DL / 2012 / Effects of huatan jiangqi capsule on the levels of multi-drug resistance-associated protein 1 in the bronchial epithelial cells of model rats with chronic obstructive pulmonary disease / Zhongguo Zhong Xi Yi Jie He Za Zhi 32:955~959
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