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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 1,145 - 1,152 (8page)
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초록· 키워드
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Purpose Recently, the 8th edition staging system of the American Joint Committee on Cancer (AJCC) for hepatocellular carcinoma (HCC) was released, including a change in T category. We aimed to validate the new AJCC system. Materials and Methods The predictive value of the new AJCC was validated in comparison to the previous edition, in a total 1,008 patients who underwent curative resection for HCC as initial treatment. Results The 2-year area under the curve values for recurrence-free survival (RFS) and overall survival (OS) were comparable in the 7th and 8th editions. Stage migration was observed in 63 patients (6.3%); from T2 to T1a for 44 patients and from T3 to T4 for 19 patients. The RFS and OS were not different between T1a and T1b in the 8th edition. For solitary tumors ≤ 2 cm, those with microvascular invasion had lower RFS and OS values than those without although they were all classified as T1a in the 8th edition. Tumors involving a major branch of the portal or hepatic vein (T4 by the 8th edition and T3b by the 7th edition) had shorter RFS and OS than multifocal tumors, at least one of which was > 5 cm (T3 by the 8th edition and T3a by the 7th edition). Conclusion The AJCC 8th edition staging system for HCC showed comparable predictive performance to the 7th edition. It is desirable in a future revision to consider sub-stratification of solitary tumors ≤ 2 cm (T1a) depending on the presence of vascular invasion, which is not included in the 8th edition.
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참고문헌 (16)
참고문헌 신청
Bray F / 2018 / Global cancer statistics 2018 : GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries / CA Cancer J Clin 68:394~424
Sherman M / 2008 / Recurrence of hepatocellular carcinoma / N Engl J Med 359:2045~2047
Portolani N / 2006 / Early and late recurrence after liver resection for hepatocellular carcinoma : prognostic and therapeutic imp-lications / Ann Surg 243:229~235
Cheng CH / 2011 / Evaluation of the new AJCC staging system for resectable hepatocellular carcinoma / World J Surg Oncol 9:114
Kee KM / 2007 / Validation of clinical AJCC/UICC TNM staging system for hepatocellular carcinoma : analysis of 5, 613 cases from a medical center in southern Taiwan / Int J Cancer 120:2650~2655
Sherman M / 2008 / Recurrence of hepatocellular carcinoma / N Engl J Med 359:2045~2047
Portolani N / 2006 / Early and late recurrence after liver resection for hepatocellular carcinoma : prognostic and therapeutic imp-lications / Ann Surg 243:229~235
Cheng CH / 2011 / Evaluation of the new AJCC staging system for resectable hepatocellular carcinoma / World J Surg Oncol 9:114
Kee KM / 2007 / Validation of clinical AJCC/UICC TNM staging system for hepatocellular carcinoma : analysis of 5, 613 cases from a medical center in southern Taiwan / Int J Cancer 120:2650~2655
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