지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 1,050 - 1,058 (9page)
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초록· 키워드
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Purpose Whether craniospinal irradiation (CSI) could be replaced by limited-field radiation in non-metastatic bifocal germinoma remains controversial. We addressed the issue based on the data from our series and the literature. Materials and Methods Data from 49 patients diagnosed with non-metastatic bifocal germinoma at our hospital during the last 10 years were collected. The Pediatric Quality of Life Inventory 4.0 was used to evaluate health-related quality of life (HRQOL). Additionally, 81 patients identified from the literature were also analyzed independently. Results In our cohort, 34 patients had tumors in the sellar/suprasellar (S/SS) plus pineal gland (PG) regions and 15 in the S/SS plus basal ganglia/thalamus (BG/T) regions. The median follow-up period was 52 months (range, 10 to 134 months). Our survival analysis showed that patients treated with CSI (n=12) or whole-brain radiotherapy (WBRT; n=34) had comparable disease-free survival (DFS; p=0.540), but better DFS than those treated with focal radiotherapy (FR; n=3, p=0.016). All 81 patients from the literature had tumors in the S/SS+PG regions. Relapses were documented in 4/45 patients treated with FR, 2/17 treated with whole-ventricle irradiation, 0/4 treated with WBRT, and 1/15 treated with CSI. Survival analysis did not reveal DFS differences between the types of radiation field (p=0.785). HRQOL analysis (n=44) in our cohort found that, compared with S/SS+PG germinoma, patients with BG/T involvement had significantly lower scores in social and school domains. However, HRQOL difference between patients treated with CSI and those not treated with CSI was not significant. Conclusion In patients with non-metastatic bifocal germinoma, it is rational that CSI could be replaced by limited-field radiation. HRQOL in patients with BG/T involvement was poorer.
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등록된 정보가 없습니다.
참고문헌 (30)
참고문헌 신청
이승훈 / 2017 / Nationwide Population-Based Incidence and Survival Rates of Malignant Central Nervous System Germ Cell Tumors in Korea, 2005-2012 / Cancer Research and Treatment 49(2):494~501
Murray MJ / 2013 / Highlights from the Third International Central Nervous System Germ Cell Tumour Symposium : laying the foundations for future consensus / Ecancermedicalscience 7:333
Gao Y / 2014 / Clinicopathological and immunohistochemical features of primary central nervous system germ cell tumors : a 24-years experience / Int J Clin Exp Pathol 7:6965~6972
Wong TT / 2008 / Germinoma involving the basal ganglia in children / Childs Nerv Syst 24:71~78
Rasalkar DD / 2010 / Atypical location of germinoma in basal ganglia in adolescents : radiological features and treatment outcomes / Br J Radiol 83:261~267
Murray MJ / 2013 / Highlights from the Third International Central Nervous System Germ Cell Tumour Symposium : laying the foundations for future consensus / Ecancermedicalscience 7:333
Gao Y / 2014 / Clinicopathological and immunohistochemical features of primary central nervous system germ cell tumors : a 24-years experience / Int J Clin Exp Pathol 7:6965~6972
Wong TT / 2008 / Germinoma involving the basal ganglia in children / Childs Nerv Syst 24:71~78
Rasalkar DD / 2010 / Atypical location of germinoma in basal ganglia in adolescents : radiological features and treatment outcomes / Br J Radiol 83:261~267
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