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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 925 - 933 (9page)
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Objective We sought to determine if the links between and within the default mode network (DMN) and dorsal attention network (DAT) exhibited different conditions according to catechol-O-methyltransferase (COMT) gene polymorphism in relationship to attention-deficit hyperactivity disorder (ADHD) symptoms.Methods Fifty-seven children with ADHD and 48 healthy controls (HCs) were administered an intelligence test, the Children’s Depression Inventory, the Korean ADHD rating scale, and continuous performance test. Resting-state brain functional MRI scans were obtained, and COMT genotyping was performed to distinguish valine carriers and methionine homozygotes.Results Compared to controls, children with ADHD showed increased ADHD scale scores, increased visual commission errors, and increased functional connectivity (FC) within the DMN and DAT. Compared to all children with ADHD, children with the methionine homozygote and those who were valine carriers showed increased FC within the DMN and DAT and decreased FC between the DMN and DAT. FC within the DMN was also increased in HC valine carriers compared to HC children with the methionine homozygote, and in children with ADHD who were valine carriers compared to HC valine carriers.Conclusion We observed increased brain connectivity within the DMN and DAT and altered brain connectivity within and between the DMN and DAT associated with COMT polymorphism in children with ADHD.
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등록된 정보가 없습니다.
참고문헌 (67)
참고문헌 신청
Moffitt TE / 2015 / Is adult ADHD a childhood-onset neurodevelopmental disorder? Evidence from a four-decade longitudinal cohort study / Am J Psychiatry 172:967~977
Polanczyk G / 2007 / The worldwide prevalence of ADHD : a systematic review and metaregression analysis / Am J Psychiatry 164:942~948
Lionel AC / 2011 / Rare copy number variation discovery and cross-disorder comparisons identify risk genes for ADHD / Sci Transl Med 95:95ra75
Pingault JB / 2015 / Genetic and environmental influences on the developmental course of attention-deficit/hyperactivity disorder symptoms from childhood to adolescence / JAMA Psychiatry 72:651~658
Franke B / 2009 / Genome-wide association studies in ADHD / Hum Genet 126:13~50
Polanczyk G / 2007 / The worldwide prevalence of ADHD : a systematic review and metaregression analysis / Am J Psychiatry 164:942~948
Lionel AC / 2011 / Rare copy number variation discovery and cross-disorder comparisons identify risk genes for ADHD / Sci Transl Med 95:95ra75
Pingault JB / 2015 / Genetic and environmental influences on the developmental course of attention-deficit/hyperactivity disorder symptoms from childhood to adolescence / JAMA Psychiatry 72:651~658
Franke B / 2009 / Genome-wide association studies in ADHD / Hum Genet 126:13~50
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