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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 563 - 565 (3page)
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초록· 키워드
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ObjectiveaaWe tested for association of the catechol-O-methyltransferase (COMT) Val158-Met (rs4680) polymorphism with attention-deficit hyperactivity disorder (ADHD) using family-based test in Korean trios.
MethodsaaA total of 181 subjects with ADHD along with both of their biological parents were recruited from University Hospitals in Korea. We performed a transmission disequilibrium test (TDT) on 181 trios.
ResultsaaIn the TDT, we found the over-transmission of the Val allele in children with ADHD (χ2=4.21, p=0.040).
ConclusionaaThese results suggest that the COMT Val158-Met polymorphism is associated with ADHD among the Korean population. However, this study must be replicated in larger populations.
목차
등록된 정보가 없습니다.
참고문헌 (16)
참고문헌 신청
Biederman J / 2005 / Attention-deficit hyperactivity disorder / Lancet 366 : 237 ~ 248
Cardon LR / 2003 / Population stratification and spurious allelic association / Lancet 361 : 598 ~ 604
Del Campo N / 2011 / The roles of dopamine and noradrenaline in the pathophysiology and treatment of attention-deficit/hyperactivity disorder / Biol Psychiatry 69 : e145 ~ e1
Eisenberg J / 1999 / Haplotype relative risk study of Catechol-O-Methyltransferease (COMT) and attention deficit hyperactivity disorder (ADHD): association of the high-enzyme
Evangelou E / 2006 / Family-based versus unrelated case-control design for genetic associations / PloS Genet 2 : e123 ~
Cardon LR / 2003 / Population stratification and spurious allelic association / Lancet 361 : 598 ~ 604
Del Campo N / 2011 / The roles of dopamine and noradrenaline in the pathophysiology and treatment of attention-deficit/hyperactivity disorder / Biol Psychiatry 69 : e145 ~ e1
Eisenberg J / 1999 / Haplotype relative risk study of Catechol-O-Methyltransferease (COMT) and attention deficit hyperactivity disorder (ADHD): association of the high-enzyme
Evangelou E / 2006 / Family-based versus unrelated case-control design for genetic associations / PloS Genet 2 : e123 ~
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